Region Study period Number of cases Incidencea Prevalenceb Reference Northern Europe Norway 1986–1995 17 1.3 8.5 [9] Sweden 1992–2005 199 1.22 16.2 [8] Netherlands 2000–2007 519 0.5 6.0 [12] UK…
Fig. 3.1 Absolute cumulative risk for colorectal dysplasia or cancer over time among patients with UC and those with PSC-UC [1] Given the apparent increased incidence of colorectal neoplasia in…
and James R. BurtonJr.1 (1) University of Colorado Hospital, Anschutz Outpatient Pavilion, 7th Floor, Transplant Center, 1635 Aurora Court, B154, Aurora, CO 80045, USA James R. BurtonJr. Email: James.Burton@UCDenver.edu KeywordsCholangiocarcinomaHepatocellular carcinomaGallbladder carcinoma Technical…
Fig. 15.1 (a–c) The typical steps of percutaneous transhepatic drainage. Needle passes are performed with injection of contrast until the biliary system is identified, often from access of a relatively…
Fig. 11.1 Bile acid physiology and circulation: an avenue for therapeutic applications. Bile acids (BAs) are synthesized by hepatocytes and subsequently secreted into canalicular bile by means of specialized hepatocyte…
Fig. 10.1 Itch pathways. The two main peripheral itch pathways include the histaminergic pathway (red line stimulated by histamine) and the non-histaminergic pathway (blue line stimulated by a number of…
Fig. 17.1 PSC recurrence-free survival after transplant (From: Campsen et al. [8]) Living Donor Liver Transplantation In terms of recurrent PSC after LDLT, there is limited information of about posttransplant…
© Springer International Publishing Switzerland 2017Lisa M. Forman (ed.)Primary Sclerosing Cholangitis10.1007/978-3-319-40908-5_16 16. Liver Transplantation for PSC Kendra Conzen1 and Trevor L. Nydam1 (1) Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora,…
Fig. 12.1 A schematic overview of possible therapeutic targets, underlying mechanistic pathways, and pathogenesis of PSC: bile acid composition, detoxification, gut microbiota, hepatic fibrosis, adaptive and innate immune system activation,…
Diagnostic templates PSC and AIH PSC and PBC Clinical criteria Histological or cholangiographic PSC [15]: Portal tract edema and fibrosis Bile duct loss or periductal fibrosis Focal biliary strictures and…
