Fig. 12.1 The GH/IGF-1 axis and its role in linear growth. The hypothalamic release of growth hormone releasing hormone (GHRH) stimulates the pulsatile release of growth hormone (GH) from the…
Fig. 51.1 Conceptual scheme of the domains and variables involved in a quality-of-life assessment. The x axis represents subjective perceptions of health, the y axis represents objective health status, the…
Fig. 34.1 Azathioprine/6-mercaptopurine metabolism pathways. AZA azathioprine, GMPS guanosine monophosphate synthetase, HPRT hypoxanthine phosphoribosyltransferase, IMPDH inosine monophosphate dehydrogenase, 6-MMP 6-methylmercaptopurine, 6-MP 6-mercaptopurine, 6-TG 6-thioguanine, 6-TIMP 6-thioinosine monophosphate, TPMT thiopurine S-methyltransferase,…
Fig. 7.1 Yearly Crohn disease activity over the first 10 years after diagnosis in a Danish population of children diagnosed prior to 15 years of age (Data from Langholz et…
Fig. 13.1 Bone modeling and remodeling. (a) Bone remodeling takes place in both adults and children. It can occur in either trabecular or cortical bone as a consequence of microfractures,…
Fig. 55.1 Timing in molecular alterations in sporadic colorectal cancer and colitis-associated colorectal cancer (From Gastroenterology, 2004) [4] IBD-associated CRCs share several features in common with sporadic CRC. First, they…
Immunization Type Route of administration Patient age at time of recommended administration Hepatitis B Inactivated Parenteral 0–1 year (three doses) Diphtheria and tetanus toxoids and acellular pertussis Inactivated Parenteral 2–6…
Safe to use when indicated Limited data but appear safe Contraindicated Oral, topical mesalamine Olsalazine Methotrexate Sulfasalazine Azathioprine/6-MP Thalidomide Corticosteroids Biologics Diphenoxylate Total parenteral nutrition Cyclosporine Loperamide Metronidazole Ciprofloxacina aNot…
From FDA’s Draft Guidance for Industry: General Clinical Pharmacology Considerations for Pediatric Studies for Drugs and Biological Products, Dec 2014 For conditions where the disease progression and response to intervention…
© Springer International Publishing AG 2017Petar Mamula, Andrew B. Grossman, Robert N. Baldassano, Judith R. Kelsen and Jonathan E. Markowitz (eds.)Pediatric Inflammatory Bowel Disease10.1007/978-3-319-49215-5_47 47. Clinical Trials (Clinical Perspective) Salvatore Cucchiara1 and Marina Aloi1 (1) Pediatric Gastroenterology and Liver Unit,…
