Clinical Management of the Adult Kidney Transplant Recipient
Key Points • Kidney transplantation remains the preferred modality for managing individuals with kidney failure, with superior outcomes in terms of patient survival and quality of life. • Availability of…
read more
Global Considerations in Kidney Disease: The Pacific Islands and Islands of the Caribbean
Key points • The burden of chronic kidney disease is increasing in the small island developing states, largely driven by growth in noncommunicable chronic illnesses such as diabetes mellitus. •…
read more
The Immunobiology of Transplantation
Key Points • Allograft rejection occurs because the recipient’s immune system recognizes the donor’s human leukocyte antigens (HLAs) as nonself through three pathways. In the direct pathway, recipient CD8 T…
read more
Disaster Nephrology
Key Points • During massive disasters, the entire spectrum of patients with kidney diseases (i.e., those with acute kidney injury, chronic kidney disease not on kidney replacement therapy, and kidney…
read more
Chronic Kidney Disease of Uncertain Etiology
Key Points • A number of geographic regions around the world have an unexpectedly high prevalence of kidney disease among persons without previously identified risk factors for kidney disease. •…
read more
Kidney Replacement Therapy (Dialysis and Transplantation) in Children
Key Points • End-stage kidney failure (ESKF) in children has multiple and far-reaching clinical consequences, including a major impact on growth and development. • The most common causes of ESKF…
read more
Global Considerations in Kidney Disease: Africa
Key points • The growing burden of kidney disease in Africa is driven by high rates of infectious disease, noncommunicable disease, pregnancy-related disease, and injuries. • In most African countries,…
read more
Cystic Kidney Diseases
Key Points • Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, characterized by progressive cyst development, renal enlargement, and eventual kidney function decline. The disease…
read more
Chronic Kidney Disease–Mineral Bone Disorder
Key Points • Changes in mineral metabolism parameters occur as early as stage 2 chronic kidney disease (CKD), most commonly with increased serum fibroblast growth factor 23 concentrations. • Pi…
read more
