Fig. 10.1 Itch pathways. The two main peripheral itch pathways include the histaminergic pathway (red line stimulated by histamine) and the non-histaminergic pathway (blue line stimulated by a number of…
Fig. 11.1 Bile acid physiology and circulation: an avenue for therapeutic applications. Bile acids (BAs) are synthesized by hepatocytes and subsequently secreted into canalicular bile by means of specialized hepatocyte…
Fig. 17.1 PSC recurrence-free survival after transplant (From: Campsen et al. [8]) Living Donor Liver Transplantation In terms of recurrent PSC after LDLT, there is limited information of about posttransplant…
© Springer International Publishing Switzerland 2017Lisa M. Forman (ed.)Primary Sclerosing Cholangitis10.1007/978-3-319-40908-5_16 16. Liver Transplantation for PSC Kendra Conzen1 and Trevor L. Nydam1 (1) Division of Transplant Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora,…
Fig. 12.1 A schematic overview of possible therapeutic targets, underlying mechanistic pathways, and pathogenesis of PSC: bile acid composition, detoxification, gut microbiota, hepatic fibrosis, adaptive and innate immune system activation,…
Diagnostic templates PSC and AIH PSC and PBC Clinical criteria Histological or cholangiographic PSC [15]: Portal tract edema and fibrosis Bile duct loss or periductal fibrosis Focal biliary strictures and…
First author Wilschanski [7] Gregorio [5] Feldstein [4] Miloh [6] Deneau [3] All studies Year published 1995 2001 2003 2009 2013 1995–2013 # Patients (n) 32 9 27 52 47…
