Impedance-pH Testing
Pharmacologic treatment of gastroesophageal reflux disease is based upon gastric acid suppression with proton pump inhibitors (PPIs). In many patients, symptoms persist despite PPI treatment. For some, ongoing symptoms may…
High-Resolution Manometry and Esophageal Pressure Topography
Although conventional manometry set the basis for the diagnosis of esophageal motility disorders, the large axial spacing between recording sites leaves large portions of the esophagus unevaluated and vulnerable to…
Benign and Malignant Esophageal Diseases
Nicholas J. Shaheen, MD, MPH, Editor The esophagus is the unsung hero of the chest. In every literary and proverbial setting, the heart gets top billing. For instance, if one…
Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition whereby infiltration of eosinophils into the esophageal mucosa leads to symptoms of esophageal dysfunction. EoE is encountered in a substantial proportion of…
Treatment Strategies for Esophageal Cancer
The treatment of esophageal cancer has evolved considerably in the past decade and depends largely on the extent of disease at the time of presentation. For disease confined to the…
Endoscopic Therapy for Barrett’s Esophagus and Early Esophageal Adenocarcinoma
Endoscopic therapy for Barrett’s esophagus is feasible and likely to decrease the future risk of development of esophageal adenocarcinoma. The most commonly used therapy is radiofrequency ablation, which has been…
Screening and Risk Stratification for Barrett’s Esophagus
Barrett’s esophagus (BE) and gastroesophageal reflux disease are the strongest risk factors for esophageal adenocarcinoma. To reduce the clinical impact of this disease, endoscopic screening to detect BE has been…
Surgical Management of Gastroesophageal Reflux Disease
Antireflux surgery has become a well-established therapy for gastroesophageal reflux disease (GERD) and its complications. The popularization of minimally invasive surgical techniques has brought about a revolution in the use…
Novel Pharmaceutical Approaches to Reflux Disease
Acid suppression, with proton pump inhibitors (PPI), is the mainstay of therapy for reflux disease; despite this, symptoms and injury persist in many patients. Novel approaches have focused on (1)…
Extraesophageal Manifestations of Gastroesophageal Reflux Disease
This article discusses the current state of knowledge regarding the relationship between gastroesophageal reflux disease (GERD) and pulmonary and ear/nose/throat manifestations of reflux and outlines the recent developments in the…
