Chapter Outline THE GLOBAL IMPACT AND CHALLENGES, 1161 OUTCOME MEASURES AND CLINICAL TRIALS IN GLOMERULONEPHRITIS, 1163 QUANTIFICATION OF THE BENEFITS OF PROTEINURIA REDUCTION, 1163 Membranous Glomerulonephritis, 1164 Focal Segmental Glomerulosclerosis,…
Chapter Outline BIOMARKER DEFINITION, 927 PROCESS OF BIOMARKER DISCOVERY, ASSAY VALIDATION, AND QUALIFICATION IN A CLINICAL CONTEXT, 927 Phase 1: Discovery of Potential Biomarkers through Hypothesis-Generating Exploratory Studies, 927 Phase…
Chapter Outline BIOMARKER DEFINITION, 927 PROCESS OF BIOMARKER DISCOVERY, ASSAY VALIDATION, AND QUALIFICATION IN A CLINICAL CONTEXT, 927 Phase 1: Discovery of Potential Biomarkers through Hypothesis-Generating Exploratory Studies, 927 Phase…
Chapter Outline SAFETY AND COMPLICATIONS OF BIOPSIES, 915 PERFORMING THE BIOPSY, 918 BIOPSY SPECIMEN HANDLING, 919 LIGHT MICROSCOPY, 919 Staining for Light Microscopy, 919 Examination of the Biopsy Specimen by…
Chapter Outline DEVELOPMENTAL PROGRAMMING, 694 DEVELOPMENTAL PROGRAMMING IN THE KIDNEY, 694 Plausibility of the Nephron Number Hypothesis, 695 Evidence for Programming in the Kidney, 696 PROGRAMMING OF RENAL FUNCTION AND…
Chapter Outline STRUCTURAL CHANGES IN THE AGING KIDNEY, 727 Gross, 727 Microscopic, 727 Biologic Mediators and Potential Modulators of Age-Related Renal Fibrosis, 728 FUNCTIONAL CHANGES IN THE AGING KIDNEY, 735…
Chapter Outline SEX AND CHRONIC KIDNEY DISEASE , 655 Factors Related to Sex Differences, 657 Oral Contraceptives, Hormone Replacement Therapy, and Kidney Disease, 659 Summary, 660 RACE, ETHNICITY, AND CHRONIC…
Chapter Outline THE NEED TO DEFINE RISK IN CHRONIC KIDNEY DISEASE , 669 Definition of a Risk Factor, 670 Epidemiologic Methods for Identifying Risk Factors, 670 RISK FACTORS AND MECHANISMS…
Chapter Outline MAJOR ARTERIES AND VEINS, 83 Hydraulic Pressure Profile of the Renal Circulation, 85 TOTAL RENAL BLOOD FLOW , 85 INTRARENAL BLOOD FLOW DISTRIBUTION, 87 Vascular-Tubule Relations, 87 Cortical…
Chapter Outline CELLULAR ORIGIN OF EICOSANOIDS, 355 CYCLO-OXYGENASE PATHWAY, 355 Molecular Biology, 355 Regulation of Cyclo-Oxygenase Gene Expression, 357 Regulation of Cyclo-Oxygenase Expression by Antiinflammatory Steroids, 357 Enzymatic Chemistry, 357…
