Diagnosis of Barrett’s Esophagus
Abstract Barrett’s esophagus is a condition in which normal stratified squamous epithelium of the esophagus is replaced with columnar epithelium. It is the primary precursor lesion for esophageal adenocarcinoma and…
Metaplasia and Dysplasia in Barrett’s Esophagus
Abstract This chapter provides details regarding the normal anatomy and histology of gastroesophageal junction along with histologic features of Barrett’s esophagus (BE). In addition, the clinical and pathologic aspects of…
Genetics and Biomarkers in Barrett’s Esophagus and Esophageal Adenocarcinoma
Abstract Esophageal adenocarcinoma (EAC) is a very heterogeneous disease and despite rapid advances in molecular technology, including sequencing the major driver mutations in the progression of its precursor, Barrett’s esophagus…
Fluctuating Risk Factors and Epidemiology
Abstract Barrett’s esophagus (BE) is an acquired condition associated with severe gastroesophageal reflux disease (GERD) and has a malignant predisposition. The overall prevalence of BE in general population varies between…
A Disease Entity Is Identified
Abstract Barrett’s esophagus (BE) is the presence of metaplastic columnar epithelium in the lower portion of the esophagus, which is normally lined with stratified squamous epithelium. The main cause of…
