Abstract Chronic kidney disease (CKD) is a growing global issue, currently affecting approximately 10% of the population. Optimal care of these patients must encompass their complex medical issues, aiming not…
Abstract This chapter will review core questions and concepts of chronic kidney disease (CKD) in older adults including physiological changes associated with aging, identification and epidemiology of CKD in older…
Abstract Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, affecting an estimated 10% of the world population. There are many causes for CKD, including familial…
Abstract In this chapter, we focus on assessment of glomerular filtration rate (GFR) as an index of overall kidney function. The GFR cannot be measured directly. Instead, it is assessed…
Chapter Outline THE GLOBAL IMPACT AND CHALLENGES, 1161 OUTCOME MEASURES AND CLINICAL TRIALS IN GLOMERULONEPHRITIS, 1163 QUANTIFICATION OF THE BENEFITS OF PROTEINURIA REDUCTION, 1163 Membranous Glomerulonephritis, 1164 Focal Segmental Glomerulosclerosis,…
Chapter Outline BIOMARKER DEFINITION, 927 PROCESS OF BIOMARKER DISCOVERY, ASSAY VALIDATION, AND QUALIFICATION IN A CLINICAL CONTEXT, 927 Phase 1: Discovery of Potential Biomarkers through Hypothesis-Generating Exploratory Studies, 927 Phase…
Chapter Outline BIOMARKER DEFINITION, 927 PROCESS OF BIOMARKER DISCOVERY, ASSAY VALIDATION, AND QUALIFICATION IN A CLINICAL CONTEXT, 927 Phase 1: Discovery of Potential Biomarkers through Hypothesis-Generating Exploratory Studies, 927 Phase…
Chapter Outline SAFETY AND COMPLICATIONS OF BIOPSIES, 915 PERFORMING THE BIOPSY, 918 BIOPSY SPECIMEN HANDLING, 919 LIGHT MICROSCOPY, 919 Staining for Light Microscopy, 919 Examination of the Biopsy Specimen by…
Chapter Outline DEVELOPMENTAL PROGRAMMING, 694 DEVELOPMENTAL PROGRAMMING IN THE KIDNEY, 694 Plausibility of the Nephron Number Hypothesis, 695 Evidence for Programming in the Kidney, 696 PROGRAMMING OF RENAL FUNCTION AND…
Chapter Outline STRUCTURAL CHANGES IN THE AGING KIDNEY, 727 Gross, 727 Microscopic, 727 Biologic Mediators and Potential Modulators of Age-Related Renal Fibrosis, 728 FUNCTIONAL CHANGES IN THE AGING KIDNEY, 735…
