Differential The main histologic finding in clinically acute biliary obstruction is a bile ductular reaction, which may be accompanied by lobular cholestasis but has minimal lobular inflammatory changes. However, a…

Minimal to mild nonspecific chronic portal inflammation is common in potential donor liver biopsies, but if the portal inflammation is diffuse or more than mild, the donor may have an…

In most cases, the hepatitic injury will resolve after stopping the drug, but it may take months for the liver enzymes to completely normalize. In general, cases with significant cholestasis…

The inflammatory grade is typically determined by adding up the individual scores for inflammation in the portal tracts, interface activity, and lobular inflammation to reach a composite inflammatory grade, although…

Differential The most common mimic of the globules of α1-antitrypsin deficiency is megamitochondria. The location can often be a helpful clue because megamitochondria tend to be randomly distributed, whereas the…

The amount of fat is generally scored as minimal (less than 5%), mild (6% to 33%), moderate (34% to 66%), or marked (more than 67%). The general consensus is that…

When cavernous hemangiomas are greater than 8 cm in diameter, they are called giant cavernous hemangiomas. Their histologic findings are similar to that of smaller hemangiomas, but they are more…

Turner Syndrome Turner syndrome is caused by monosomy X (karyotype 45,X) in which all or portions of one copy of the X chromosome are missing in females. Affected individuals can…

The specific type of amyloid cannot be determined by the hematoxylin and eosin (H&E) findings. However, amyloid deposits can be further subtyped on liver biopsy by immunostains, by laser microdissection…

Clinical Findings Most infants with biliary atresia are term infants with normal birth weights. Infants present within the first 1 to 6 weeks of life with jaundice, pale stools, and…