Pediatric Cholestatic Liver Disease Marcela Salomao, MD 14.1 INTRODUCTION Pediatric cholestatic liver diseases are a heterogeneous group of illnesses, including infections, metabolic disorders, congenital malformations, and many others.1 Liver biopsy…
Autoimmune Hepatitis Rish K. Pai, MD, PhD 12.1 INTRODUCTION Autoimmune hepatitis is defined as an unresolving hepatitis characterized by an aberrant immune response against self-liver antigens. This aberrant immune response…
Parasites in the Liver Bobbi S. Pritt, MD, MSc 9.1 INTRODUCTION Parasites are an important cause of infections in the liver and biliary tract and are responsible for significant morbidity…
Granulomatous Liver Disease Vishal S. Chandan, MD Tsung-Teh Wu, MD, PhD 11.1 INTRODUCTION Granulomas are localized collections of macrophages and other inflammatory cells, such as lymphocytes, that usually develop in…
Viral Hepatitis Roger K. Moreira, MD Douglas A. Simonetto, MD 8.1 GRADING AND STAGING OVERVIEW In a fashion somewhat analogous to tumor pathology—where grade refers to features that reflect disease…
Other Infections of the Liver Michael S. Torbenson, MD 10.1 INTRODUCTION This chapter discusses nonviral and nonparasitic infections of the liver, though infections that are primarily granulomatous are discussed with…
The Almost Normal Liver Biopsy Michael S. Torbenson, MD 7.1 OVERVIEW Liver biopsies can sometimes be almost normal on histological examination, even when performed for clinical indication. The clinical indication…
Electron Microscopy Taofic Mounajjed, MD 5.1 INTRODUCTION The rise of immunohistochemical, molecular, and serologic techniques in pathology over the past decades has somewhat sidelined certain diagnostic uses of the more…
Basic Patterns of Injury in Medical Liver Pathology Roger K. Moreira, MD A pattern of injury represents individual histologic findings that cluster into a meaningful and recognizable histologic pattern. Identification…
The Language of Liver Pathology: Definitions of Key Terms Michael S. Torbenson, MD 3.1 INTRODUCTION Like all medical disciplines, liver pathology has its own vocabulary used to describe histological findings….
