Distinguishing Colonic Neoplasms from Neoplasms from Other Sites There are two types of problems one encounters with respect to metastatic carcinomas of the colon. The first is determining if a…
Secondary Tumors The large bowel may be the site of metastasis or extension from a number of tumors. It may also be involved by direct invasion or extension, intraperitoneal seeding,…
Serrated Polyps Serrated Adenomas Serrated adenomas constitute 1% to 2% of colorectal adenomas (261,262). Patients range in age from 15 to 88 years, with a mean of 63 years. The…
Aberrant Crypt Foci Aberrant crypt foci (ACF) constitute putative preneoplastic lesions originally described in experimental animal models of colorectal cancer (253,254,255). ACF have been proposed as intermediate biomarkers in carcinogenesis…
Colon Cancer Prevention Colon cancer prevention strategies fall into three major categories: (a) identification and removal of precursor and early lesions, (b) dietary alterations, and (c) chemoprevention. Disease prevention falls…
Colonic Adenomas and Carcinomas Colorectal carcinoma is one of the most common neoplasms affecting individuals living in industrialized nations. Colorectal cancer is the fourth ranking cancer worldwide, accounting for approximately…
Introduction The large intestine gives rise to a host of neoplasms. In this chapter we will focus on epithelial neoplasms. Neuroendocrine tumors are covered in Chapter 17, hematologic malignancies in…
Online Chapter 3 CASE 3.1 CLINICAL HISTORY 50-year-old woman with abdominal pain. FIGURE 3.1A FIGURE 3.1B FIGURE 3.1C FIGURE 3.1D FINDINGS T2 MR (A) demonstrates innumerable subcenti-meter T2 bright structures…
Inflammatory Bowel Disease Chronic idiopathic inflammatory bowel disease (IBD) includes two chronic gastrointestinal disorders of unknown etiology: Ulcerative colitis (UC) and Crohn disease (CD). The natural history of IBD differs…
