Gastroesophageal Reflux Disease
Gary W. Falk, MD, MS, Consulting Editor Gastroesophageal reflux disease (GERD) remains one of the most common problems encountered in gastrointestinal clinical practice with over 8 million patient visits in…
GASTROENTEROLOGY
Eosinophilic Esophagitis
Twenty years have passed since eosinophilic esophagitis was first recognized as a new and distinct entity. Current treatment modalities for eosinophilic esophagitis include the “3 Ds”: drugs, allergen avoidance with…
Steroids in Pediatric Eosinophilic Esophagitis
Swallowed fluticasone and oral viscous budesonide are effective first-line therapies for eosinophilic esophagitis in children. Side effects are minimal without evidence of Cushing syndrome, as seen in treatment with systemic…
Dietary Treatment of Eosinophilic Esophagitis
Emerging evidence supports impaired epithelial barrier function as the key initial event in the development of eosinophilic esophagitis (EoE) and other allergic diseases. Symptom resolution, histologic remission, and prevention of…
Steroid Treatment of Eosinophilic Esophagitis in Adults
Topical steroid therapy has been used to treat eosinophilic esophagitis (EoE) for more than 15 years. We review the treatment trials of topical steroid therapy in adult patients with EoE. Currently,…
Eosinophilic Esophagitis
A validated disease-specific symptom-assessment tool for eosinophilic esophagitis (EoE) has yet to be approved by regulatory authorities for use in clinical trials. Relevant end points for daily practice include EoE-related…
Eosinophilic Gastroenteritis and Related Eosinophilic Disorders
Eosinophilic gastroenteritis (EGE) represents one member within the spectrum of diseases collectively referred to as eosinophilic gastrointestinal disorders, which includes eosinophilic esophagitis (EoE), gastritis, enteritis, and colitis. EGE is less…
Clinical Implications and Pathogenesis of Esophageal Remodeling in Eosinophilic Esophagitis
In eosinophilic esophagitis (EoE), remodeling changes are manifest histologically in the epithelium and subepithelium where lamina propria fibrosis, expansion of the muscularis propria, and increased vascularity occur. The clinical symptoms…
Allergic Mechanisms in Eosinophilic Esophagitis
Eosinophilic esophagitis is rapidly increasing in incidence. It is associated with food antigen–triggered, eosinophil-predominant inflammation, and the pathogenic mechanisms have many similarities to other chronic atopic diseases. Studies in animal…
Genetic and Epigenetic Underpinnings of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a complex, polygenic disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a…
