Liver Involvement in Systemic Diseases Lizhi Zhang, MD 19.1 INTRODUCTION Just as primary liver disease can affect other organ systems in the body, the liver may be affected in many…

Cytopathology of the Liver Yajue Huang, MD Andrea Jones, MD Michael Rivera, MD 22.1 INTRODUCTION Fine needle aspiration (FNA) is a commonly used approach to determine the nature of a…

Imaging of Liver Tumors Michael L. Wells, MD Sudhakar K. Venkatesh, MD Radiologic evaluation represents a critical component of liver tumor detection and characterization. After discovery of a liver mass,…

Fatty Liver Disease: Alcoholic and Nonalcoholic Maxwell L. Smith, MD 16.1 INTRODUCTION This chapter covers the spectrum of fatty liver disease from sim-ple steatosis to severely active steatohepatitis. The chapter…

Cholestatic Liver Disease and Biliary Tract Disease Jason Lewis, MD 13.1 INTRODUCTION Cholestasis is defined as impaired bile flow. It may be secondary to either hepatocyte abnormalities or compromise of…

Molecular Genetics of Liver Diseases Rondell P. Graham, MBBS 23.1 INTRODUCTION Molecular techniques are increasingly used in the characterization of diseases and specimens in clinical practice and research. These scientific…

Drug Effects Michael S. Torbenson, MD 15.1 OVERVIEW The acronym DILI, which stands for “drug-induced liver injury”, is commonly used in the literature on drug reactions. In the United States,…

Iron Overload and Liver Pathology Vishal S. Chandan, MD Michael S. Torbenson, MD 17.1 INTRODUCTION The medical community has recognized that iron accumulation causes liver disease for several hundred years,…

Pediatric Cholestatic Liver Disease Marcela Salomao, MD 14.1 INTRODUCTION Pediatric cholestatic liver diseases are a heterogeneous group of illnesses, including infections, metabolic disorders, congenital malformations, and many others.1 Liver biopsy…

Autoimmune Hepatitis Rish K. Pai, MD, PhD 12.1 INTRODUCTION Autoimmune hepatitis is defined as an unresolving hepatitis characterized by an aberrant immune response against self-liver antigens. This aberrant immune response…