Bile Acid and Colorectal Cancer
Fig. 14.1 The schema of the randomized control study [36]. Eligible criteria included the removal of one or more colorectal adenomas with a diameter of 3 mm or more during a…
GASTROENTEROLOGY
Bile Acids and Cholestatic Liver Disease 3: Inborn Errors of Bile Acid Synthesis
Fig. 9.1 Simplified scheme of the two major pathways for the synthesis of bile acids from cholesterol and for their recycling. The “neutral” pathway starts with conversion of cholesterol to…
Bile Acids and Esophageal Cancer
© Springer Japan KK 2017Susumu Tazuma and Hajime Takikawa (eds.)Bile Acids in Gastroenterology10.1007/978-4-431-56062-3_13 13. Bile Acids and Esophageal Cancer Juntaro Matsuzaki1 and Hidekazu Suzuki2 (1) Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1…
Bile Acids and Pancreatic Disease
Fig. 12.1 A schema of bile acid signaling in pancreatic acinar cells. Extracellular bile acid enters pancreatic acinar cells through Na+-dependent transporter Ntcp at the luminal membrane and Na+-independent transporter…
Bile Acids and Cholestatic Liver Disease 1: Primary Biliary Cholangitis (PBC)
1. Elevated cholestatic liver enzymes (e.g., alkaline phosphatase) 2. Detectable antimitochondrial antibodies (AMA) in sera 3. The presence of chronic nonsuppurative destructive cholangitis The diagnosis of PBC is made if…
Nuclear Receptor Regulation
Fig. 4.1 Nuclear receptors regulate bile acid metabolism. Nuclear receptors that regulate expression of genes involved in bile acid metabolism are shown. FXR, PXR, and VDR respond to bile acids….
Hepatobiliary Transport of Bile Acids
Fig. 2.1 Bile acid transporters. In hepatocytes, bile acids are absorbed from the sinusoid by NTCP, and in part by OATPs, and are secreted into the bile canaliculus by BSEP….
Pharmacologic Therapies for Obesity
This article examines the transitions in pharmacological therapy for obesity. It reviews the current options approved by the Food and Drug Administration and several drugs approved for other indications that…
Hepatic Complications of Obesity
Obesity is associated with a spectrum of chronic liver disease. Because obesity increases the risk for advanced forms of liver disease (ie, cirrhosis and liver cancer), the obesity epidemic is…
Colonic Complications of Obesity
Obesity is a risk factor for colorectal cancer and adenomatous polyps. The increased prevalence of neoplasia coupled with the observation that obesity may be associated with a suboptimal bowel preparation…
