Diabetic Kidney Disease
Diabetic Kidney Disease Radica Z. Alicic Joshua J. Neumiller Katherine R. Tuttle INTRODUCTION Diabetes mellitus (DM), owing in part to the classic presenting symptom of polyuria, has long been associated…
Fibrillary and Immunotactoid Glomerulonephritis
Fibrillary and Immunotactoid Glomerulonephritis Rupali S. Avasare Samar M. Said Samih H. Nasr FIBRILLARY GLOMERULONEPHRITIS Introduction/General Considerations Fibrillary glomerulonephritis (FGN) is a rare glomerular disease first described by Rosenmann and…
Membranous Nephropathy
Membranous Nephropathy Anne M. Kouri Sonia Boyer-Sauvet Michelle M. O’Shaughnessy INTRODUCTION/GENERAL CONSIDERATIONS Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults without diabetes, and the estimated incidence…
Congenital Nephrotic Syndrome
Congenital Nephrotic Syndrome Shanthi S. Balani Sarah J. Kizilbash INTRODUCTION Nephrotic syndrome is a heterogeneous group of disorders classically characterized by a triad of massive proteinuria, hypoalbuminemia, and edema. Based…
Focal Segmental Glomerulosclerosis
Focal Segmental Glomerulosclerosis Louis-Philippe Laurin Laura H. Mariani INTRODUCTION Focal segmental glomerulosclerosis (FSGS) is a major cause of glomerular disease worldwide. It represents a histologic pattern of kidney injury rather…
Minimal Change Disease
Minimal Change Disease Chia-shi Wang Patrick H. Nachman INTRODUCTION/GENERAL CONSIDERATIONS Minimal change disease (MCD) is characterized by nephrotic syndrome and normal glomerular histology by light microscopy, with podocyte effacement on…
Extrarenal Manifestations of Nephrotic Syndrome
Extrarenal Manifestations of Nephrotic Syndrome Bryce A. Kerlin Vimal K. Derebail INTRODUCTION/GENERAL CONSIDERATIONS Three extrarenal manifestations drive much of the morbidity and mortality that results from nephrotic syndrome (NS). Edema…
Approach to the Diagnosis of Glomerular Disease
Approach to the Diagnosis of Glomerular Disease A. Neil Turner The current nomenclature for glomerulonephritis is a confusing mixture of terms derived from light microscopy and those derived from more…
Introduction to Kidney Biopsy and Basic Glomerular Pathology
Introduction to Kidney Biopsy and Basic Glomerular Pathology Lihong Bu Anthony Chang KIDNEY BIOPSY INDICATIONS AND SPECIMEN HANDLING Kidney biopsy is the gold standard to diagnose glomerular diseases. Common indications…
Introduction to the Pathogenesis of Glomerular Diseases
Introduction to the Pathogenesis of Glomerular Diseases Patrick H. Nachman Michelle N. Rheault Virginie Royal The study of glomerular disease is a rich and exciting, yet challenging field of nephrology….
