Gastric emptying scintigraphy
Introduction Gastric motility is important for the proper processing and gastric emptying (GE) of an ingested meal . The gastric motility responses to an ingested meal involve actions of several…
Breath tests for the assessment of gastroparesis
Introduction Many providers are often faced with the decision of selecting the best test available from their armamentarium to diagnose gastroparesis. This can be challenging with recent evidence showing poor…
The use of wireless motility capsule in the diagnosis and monitoring of gastroparesis
Gastroparesis Background Gastroparesis is a chronic disorder characterized by delayed gastric emptying in the absence of mechanical obstruction, which results in typical symptoms of nausea, vomiting, bloating, abdominal distention, postprandial…
Autonomic neuropathies and gastroparesis
Abbreviations AAG Autonomic autoimmune ganglionopathy ANS Autonomic nervous system ATTR Transthyretin amyloid COMPASS composite autonomic symptom score EDS Ehlers-Danlos syndrome HIV Human Immunodeficiency Virus POTS Postural orthostatic tachycardia syndrome TTR…
Gastroparesis and the brain-gut axis
Introduction Gastroparesis causes impairment in quality of life with deleterious impacts on health. Complicating our understanding of the condition is the combination of different insults which can provoke the disorder….
Pathology of gastroparesis: ICC, enteric neurons and fibrosis
Introduction Gastroparesis is a disease that affects the stomach’s motility and digestion, preventing proper stomach emptying. As a complex organ, the stomach empties both solid food and liquids at different…
Sensory dysfunction in gastroparesis
Gastroparesis occurs commonly as a complication of long-standing diabetes, but the in the largest group of patients no cause can be established and these are referred to as idiopathic gastroparesis…
Cellular pathogenesis of gastroparesis
Abbreviations Ano-1 anoctamin-1 BH4 tetrahydrobiopterin BMP-2 bone morphogenetic protein-2 BMPR BMP receptor ChAT choline acetyltransferase CSF-1 colony stimulating fator-1 CX3CR1 CX3C chemokine receptor 1 DG diabetic gastroparesis DM diabetes mellitus…
Epidemiology of gastroparesis
Introduction – the challenge Gastroparesis is commonly defined on the basis of the combination of symptoms and delayed gastric emptying, in the absence of mechanical obstruction. Therein lies a major…
Historical perspectives on gastric motility and gastroparesis
Introduction Remarkable progress has been made in the study of gastrointestinal (GI) motility, particularly gastric motility, in the last century. This progress in GI motility has proceeded from contributions of…
