Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), a disease with increasing burden in the Western world, especially in white men. Risk factors for BE include obesity, tobacco…
This article focuses on recent findings on the molecular mechanisms involved in esophageal columnar metaplasia. Signaling pathways and their downstream targets activate specific transcription factors leading to the expression of…
Gary W. Falk, MD, MS, Consulting Editor The incidence of esophageal adenocarcinoma continues to increase at an alarming rate in the Western world. While the prognosis for early esophageal adenocarcinoma…
Prasad G. Iyer, MD, MSc, FACG, FASGE, AGAF, Editor Navtej S. Buttar, MD, Editor Barrett’s esophagus (BE) is currently a field in rapid evolution. A number of well established paradigms…
Helicobacter pylori infection contributes to a variety of gastric diseases. H pylori- associated gastric cancer is diagnosed in advanced stages, and a vaccine against H pylori is desirable in parts…
The purpose of this study was to elucidate the prevalence and effect of Helicobacter pylori infection in Japanese teenagers. The study subjects were students ages 16 to 17 from one…
Conflicting data have been published on the effect of long-term proton pump inhibitor therapy on the gastric mucosa in Helicobacter pylori –infected subjects. In this article, the available data are…
Recent trends and current knowledge on the diagnosis and treatment strategy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma are reviewed. Helicobacter pylori infection plays the causative role in the pathogenesis,…
Helicobacter pylori eradication therapy for chronic gastritis achieved world-first coverage by the Japanese national health insurance scheme in 2013, making a dramatic decrease of gastric cancer–related deaths more realistic. Combining…
Helicobacter pylori infection plays a crucial role in gastric carcinogenesis. H pylori exerts oncogenic effects on gastric mucosa through complex interaction between bacterial virulence factors and host inflammatory responses. On…
