Several histologic variants of FSGS can be distinguished, including classic FSGS (also known as FSGS not otherwise specified), perihilar variant, glomerular tip variant, cellular variant, and collapsing variant. It is…
More than half of adult MCD patients will have a relapse during their lifetime, and up to one in four will become a frequent relapser, experiencing more than three episodes…
Because patients with MCD tend to have very severe proteinuria, clinicians must be alert for the presence of related complications. As in all cases of nephrotic syndrome, patients are at…
Lifestyle changes are also important. Patients should adopt a low-salt diet to reduce edema and improve blood pressure control. Exercise may help mobilize edema and allow natural diuresis, as well…
Patients with edema do not necessarily have nephrotic syndrome, since other diseases—notably congestive heart failure and cirrhosis—can present in this fashion. The diagnosis of nephrotic syndrome is suggested, however, when…
Titratable Acids. Urine contains several weak acids that serve as urinary buffers. These buffers are also called “titratable acids” because their concentration can be determined based on how much NaOH…
PREVENTION The most effective prevention strategy is to maintain euvolemia in hospitalized patients and to avoid excessive exposure to nephrotoxic agents, especially in patients with preexisting renal disease. In situations…
Patients with nephrotic syndrome are at increased risk for lower extremity, pulmonary, and renal vein thromboses (see Plate 4-35) because of urinary losses of anticoagulant proteins, such as antithrombin and…
The first manifestation of disease is typically a sharp increase in serum creatinine concentration on routine laboratory examination. Recent exposure to a known nephrotoxin strongly suggests the diagnosis of ATN,…
Once postrenal AKI is suspected, the patient should undergo further evaluation with radiographic imaging to further characterize the obstruction. MANAGEMENT The specific management of these various etiologies is discussed later…
