Wait List Management
Fig. 4.1 United Network for Organ Sharing national kidney wait list additions and composition by active status Facts and Figures Since UNOS began keeping records in 1987, over 500,000 organ…
The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients
Dyslipidemia Goal Initiate Increase Alternative TG > 500 mg/dL with LDL < 100 mg/dL TG < 500 mg/dL TLC TLC + niacin Fibrate or statin LDL 100–129 mg/dL LDL < 100 mg/dL TLC TLC + low-dose statin Ezetimibe or niacin LDL > 100 mg/dL…
Hematologic Complications of Transplantation
Medication Mechanism Incidence References mTOR inhibitors Myelosuppression 10–45 % [31] Antithymocyte globulins Myelosuppression, DITP 10–44 % [6, 19] Valproate DITP, myelosuppression 5–30 % [55] Azathioprine Myelosuppression 10–15 % [51] Ganciclovir/valganciclovir…
Drug Interactions in Solid Organ Transplant Recipients
Immunosuppressive agent Interacting agent Effect of interacting agent Recommendations/monitoring Calcineurin inhibitors Antifungals Anidulafungin No significant effect Amphotericin B Increased risk of nephrotoxicity Appropriate hydration; monitor renal function closely Caspofungin…
Kidney and Pancreas Transplantation
1 year 5 years 10 years SPK 0.039 0.161 0.329 PAK 0.178 0.462 0.577 PTA 0.198 0.460 0.605 Data is from the SRTR 2011 Annual Report. 1-year data is…
Extended Criteria Donors in Renal Transplantation
A B Age 60 or older 50–59 and two of the following characteristics Creatinine >1.5 mg/dL Hypertension History of hypertension Cause of donor death Cerebrovascular death ECD donors are…
Human Polyomavirus (HPyV) and Organ Transplantation
Screening test Sensitivity (%) Specificity (%) PPV (%) NPV (%) BK viremiaa 100 96 50 100 BK viruriab 100 92 31 100 Decoy cellsc 25 84 5 97 Urinary capsid…
Delayed Graft Function and Kidney Transplantation
Acute tubular necrosis Urological/surgical complications • Urinary leak • Lymphocele • Ureteral obstruction • Catheter obstruction • Bleeding/hematoma Vascular causes • Hypovolemia/hypoperfusion • CNI toxicity (vasoconstriction) • Thrombosis of the…
Malignancies After Transplantation and Posttransplant Lymphoproliferative Disorder
Modifiable risk factors 1. Smoking 2. Sun exposure 3. Geographical location 4. Immunosuppressive drug therapy Non–modifiable risk factors 1. Age 2. Male gender 3. White ethnicity 4. Genetic disposition 5….
Dyslipidemia After Kidney Transplantation
Study n Age (years) Cholesterol > 200 mg/dL (%) LDL > 100 mg/dL (%) HDL < 40 mg/dL (%) TG mean (mg/dL) Moore et al. [26] 214 44.7 90 97 48 195 Aakhus et al. [27]…
