Infliximab for Ulcerative Colitis
Fig. 15.1 Mucosal healing 14 weeks after introduction of infliximab. Endoscopic images of the sigmoid at baseline (upper panel) and at week 14 (lower panel) in a patient receiving infliximab…
Tacrolimus, Sirolimus, and Mycophenolate Mofetil
© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_14 14. Tacrolimus, Sirolimus, and Mycophenolate Mofetil Andreas Fischer1 and Daniel C. Baumgart1 (1) Department of Medicine, Division of Gastroenterology and Hepatology Charité Medical…
Azathioprine/6-Mercaptopurine Metabolism in Ulcerative Colitis: A Guide to Metabolite Assessment—An Evidence-Based Approach
Fig. 12.1 Azathioprine (AZA) metabolism. XO xanthine oxidase, 6-TU 6-thiouric acid, and 6-TIMP 6-thioinosine monophosphate An apparent genetic polymorphism has been observed in TPMT activity in both the Caucasian and…
Antimetabolite Therapy in Ulcerative Colitis: Azathioprine, 6-Mercaptopurine, and Methotrexate
and Javier P. Gisbert1 (1) Department of Gastroenterology, La Princesa University Hospital, Diego de Leon 62, Madrid, 28006, Spain Javier P. Gisbert Email: javier.p.gisbert@gmail.com KeywordsThiopurinesAzathioprineMercaptopurineMethotrexateUlcerative colitis Introduction Ulcerative colitis (UC) is a…
Contrast and Comparison of Mesalamine Derivatives in the Treatment of Ulcerative Colitis
Fig. 7.1 Proposed metabolic pathway of 5-ASA after oral administration. The shaded area (large intestine) indicates the site of topical action. Unformulated 5-ASA is absorbed rapidly from the small intestine,…
The Importance of Mucosal Healing in Ulcerative Colitis
Fig. 5.1 Variable appearances of mucosa in ulcerative colitis In an effort to quantify the degree of inflammation, a number of different clinical, endoscopic, and composite scoring systems have been…
Oral and Parenteral Corticosteroid Therapy in Ulcerative Colitis
Fig. 9.1 The mechanism of action of corticosteroids on the immune system Although corticosteroids can suppress inflammatory genes, they also inhibit the transcription of other genes, including osteocalcin, keratin, proopiomelanocortin…
Principles of Medical Management of Ulcerative Colitis
Induction therapy [1, 2] Maintenance therapy Mild • Oral 5-ASA • Topical 5-ASA • Topical steroid • Oral 5-ASA, with or without topical 5-ASA Moderate • Oral 5-ASA •…
The History of Medical Therapy of Ulcerative Colitis
7. Crohn BB. An historic note on ulcerative colitis. Gastroenterology. 1962;42:366–7.PubMed 8. Bassler A. Ulcerative colitis. Interstate Med J. 1913;20:705–6. 9. Brown J. The value of complete physiological rest of…
Complications: How to Prevent and Manage Them
Fig. 7.1 Critical view of safety: gentle grasper traction exposes structures in Calot’s triangle Fig. 7.2 Underpassing cystic duct and artery to obtain the critical view of safety avoids bile…
