Diabetes and Metabolic Syndrome
Fig. 23.1 Sympathetic activity measured by MSNA in normotensive controls (NT), diabetes mellitus type 2 (DM2), hypertension (HTN) and metabolic syndrome (HTN + DM2) (Modified from Huggett et al. [1])…
The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease
Fig. 22.1 Effects of RDN on BP (a) and changes in eGFR (b) over time in Symplicity HTN-1 with follow-up to 2 years (Reproduced from Symplicity HTN-1 Investigators [8], with…
Renal Denervation for Congestive Heart Failure
Fig. 20.1 Interaction of the sympathetic nervous system, kidney and activation of the renin-angiotensin-aldosterone pathway In heart failure, sympathetic stimulation leads to activation of the renin-angiotensin-aldosterone system with increased sodium…
Medtronic Ardian Symplicity™ Renal Denervation Devices
Catheter name Electrode size Ablation time Catheter configuration Guiding catheter F size compatible Arch™ and $$$; Single (2 mm) 2 min/site Non-steerable 8F Flex™ and $$$; Single (2 mm) 2…
Great Myths of Blood Pressure Effect Size in Renal Denervation
Fig. 21.1 Top: The normal distribution of blood pressures from repeated blood pressure measurements in a hypothetical patient presenting to the clinic with a ‘true’ mean blood pressure of 150…
Vincristine Local Delivery for Renal Artery Denervation
Fig. 14.1 Chemical structure of vincristine Peripheral neuropathy can be defined as a derangement in structure and function of peripheral motor, sensory, and autonomic neurons causing peripheral neuropathic symptoms and…
Obstructive Sleep Apnea
Fig. 24.1 Median systolic and diastolic BP changes after renal sympathetic denervation procedure at 3 and at 6 months of follow-up. Error bars represent interquartile range Decreases in AHI at…
Pathophysiology: The Target for Renal Denervation
Fig. 1.1 Interaction between the brain and the kidney with the effect of increasing sympathetic nerve activities. Sympathetic activation is generated in the kidney, where it reaches the heart, the…
Sympathetic Renal Denervation Using the EnligHTN Multi-electrode Ablation System: The St Jude Experience
Fig. 8.1 (a) First generation ablation system. Generator and 8 F ablation catheter. (b) Second generation generator with a touch screen The second generation generator is slimmer and has updated…
Radiofrequency and Irrigated Ablation: Principles and Potential for Renal Artery Denervation (RDN) in the Treatment of Resistant Arterial Hypertension
Fig. 18.1 Thrombus formation after renal nerve ablation. Significant intraluminal thrombus formation after renal nerve denervation are unapparent by angiography (a, d), however displayed in different OCT cross-sections (b, c,…
