Reference Subjects Treatment duration Main findings [14] 257 patients 239 controls (unexposed) 4.9 months (dexfenfluramine) 26.5 months (dexfenfluramine and phentermine) Odds ratio for cardiac valve abnormalities 12.7 for dexfenfluramine, 24.5…
Fig. 9.1 (a, b) Computed tomographic (CT) appearance of thoracic periaortitis. The perivascular tissue surrounds (a) the upper portion of descending aorta (arrow), and (b) the ascending thoracic aorta (arrow)….
Author, year Number of patients Type of study Main results Li et al. (2010) [8] 70 Histological case-control study of IgG4-thyroiditis and non-IgG4 thyroiditis IgG4-thyroiditis and non-IgG4 thyroiditis are distinct…
Grados et al. [15] Wallace et al. [13] Fernandez-Codina et al. [19] Campochiaro et al. [16] Chen et al. [17] Lin et al. [18] Inoue et al. [14]a No….
Fig. 10.1 Mediastinal tissue biopsy of a patient affected by idiopathic mediastinal fibrosis with elevated serum IgG4 levels. The pictures show fibrotic tissue with linfo-plasmacellular infiltration (a). IgG4 (b) and…
Fig. 8.1 Schematic representation of the clinical spectrum of retroperitoneal fibrosis and chronic periaortitis 8.2 Secondary Forms of RPF The clinical entities included in the spectrum of CP are idiopathic….
Gene/locus and variation/allele Population Cases Controls Odds ratio P-Value Reference HLA-B (rs3099844) Norwegian 285 PSC 298 4.8 2.6 × 10−26 Karlsen et al. [19] GPC6 (rs9524260) Norwegian 285 PSC 298…
Fig. 2.1 Myofibroblasts are central to fibrogenesis and are submitted to regulation by pro- and anti-fibrotic cytokines. Schematic and simplified view of the network of cytokines influencing ECM deposition by…
Fig. 6.1 (a) Computed tomography (CT) appearance of diffuse AIP: the pancreatic parenchyma appears diffusely hypodense in the body-tail of the pancreas on arterial phase. (b) CT appearance of focal…
© Springer International Publishing Switzerland 2017Augusto Vaglio (ed.)Systemic Fibroinflammatory DisordersRare Diseases of the Immune System10.1007/978-3-319-41349-5_5 5. Pathophysiology of IgG4-Related Disease Jochen Zwerina1 (1) Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and…
