Gadolinium-Induced Fibrosis

Sep 2, 2017 by in NEPHROLOGY Comments Off on Gadolinium-Induced Fibrosis

Study (location) Year GBCA exposure Cases of GIF/GBCA exposed patients with renal disease Notes Marckmann (Denmark) 2006 Gadodiamide 13/370 (3.5 %) Retrospective chart review: strong association of gadodiamide exposure with…

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Malignant Diseases Mimicking Retroperitoneal and Mediastinal Fibrosing Disorders

Sep 2, 2017 by in NEPHROLOGY Comments Off on Malignant Diseases Mimicking Retroperitoneal and Mediastinal Fibrosing Disorders

Anterior mediastinum Middle mediastinum Posterior mediastinum Thymoma Lymphoma Neurogenic tumor Teratoma, seminoma Pericardial cyst Bronchogenic cyst Lymphoma Bronchogenic cyst Enteric cyst Carcinoma Metastatic cyst Xanthogranuloma Parathyroid adenoma Systemic granuloma Diaphragmatic…

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Drug-Induced Fibrosing Lesions

Sep 2, 2017 by in NEPHROLOGY Comments Off on Drug-Induced Fibrosing Lesions

Reference Subjects Treatment duration Main findings [14] 257 patients 239 controls (unexposed) 4.9 months (dexfenfluramine) 26.5 months (dexfenfluramine and phentermine) Odds ratio for cardiac valve abnormalities 12.7 for dexfenfluramine, 24.5…

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Diffuse (Thoraco-Abdominal) Periaortitis

Sep 2, 2017 by in NEPHROLOGY Comments Off on Diffuse (Thoraco-Abdominal) Periaortitis

Fig. 9.1 (a, b) Computed tomographic (CT) appearance of thoracic periaortitis. The perivascular tissue surrounds (a) the upper portion of descending aorta (arrow), and (b) the ascending thoracic aorta (arrow)….

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Idiopathic Mediastinal Fibrosis

Sep 2, 2017 by in NEPHROLOGY Comments Off on Idiopathic Mediastinal Fibrosis

Fig. 10.1 Mediastinal tissue biopsy of a patient affected by idiopathic mediastinal fibrosis with elevated serum IgG4 levels. The pictures show fibrotic tissue with linfo-plasmacellular infiltration (a). IgG4 (b) and…

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Genetics of Fibroinflammatory Disorders

Sep 2, 2017 by in NEPHROLOGY Comments Off on Genetics of Fibroinflammatory Disorders

Gene/locus and variation/allele Population Cases Controls Odds ratio P-Value Reference HLA-B (rs3099844) Norwegian 285 PSC 298 4.8 2.6 × 10−26 Karlsen et al. [19] GPC6 (rs9524260) Norwegian 285 PSC 298…

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Basic Mechanisms Linking Inflammation and Fibrosis

Sep 2, 2017 by in NEPHROLOGY Comments Off on Basic Mechanisms Linking Inflammation and Fibrosis

Fig. 2.1 Myofibroblasts are central to fibrogenesis and are submitted to regulation by pro- and anti-fibrotic cytokines. Schematic and simplified view of the network of cytokines influencing ECM deposition by…

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