The Natural History of Crohn Disease in Children
Fig. 7.1 Yearly Crohn disease activity over the first 10 years after diagnosis in a Danish population of children diagnosed prior to 15 years of age (Data from Langholz et…
Inflammatory Bowel Diseases and Skeletal Health
Fig. 13.1 Bone modeling and remodeling. (a) Bone remodeling takes place in both adults and children. It can occur in either trabecular or cortical bone as a consequence of microfractures,…
Malignant Tumors Arising in Inflammatory Bowel Disease
Fig. 55.1 Timing in molecular alterations in sporadic colorectal cancer and colitis-associated colorectal cancer (From Gastroenterology, 2004) [4] IBD-associated CRCs share several features in common with sporadic CRC. First, they…
Immunizations in the Child with Inflammatory Bowel Disease
Immunization Type Route of administration Patient age at time of recommended administration Hepatitis B Inactivated Parenteral 0–1 year (three doses) Diphtheria and tetanus toxoids and acellular pertussis Inactivated Parenteral 2–6…
Inflammatory Bowel Disease in Pregnancy
Safe to use when indicated Limited data but appear safe Contraindicated Oral, topical mesalamine Olsalazine Methotrexate Sulfasalazine Azathioprine/6-MP Thalidomide Corticosteroids Biologics Diphenoxylate Total parenteral nutrition Cyclosporine Loperamide Metronidazole Ciprofloxacina aNot…
Clinical Trials (Industry/Regulatory Perspective)
From FDA’s Draft Guidance for Industry: General Clinical Pharmacology Considerations for Pediatric Studies for Drugs and Biological Products, Dec 2014 For conditions where the disease progression and response to intervention…
Clinical Trials (Clinical Perspective)
© Springer International Publishing AG 2017Petar Mamula, Andrew B. Grossman, Robert N. Baldassano, Judith R. Kelsen and Jonathan E. Markowitz (eds.)Pediatric Inflammatory Bowel Disease10.1007/978-3-319-49215-5_47 47. Clinical Trials (Clinical Perspective) Salvatore Cucchiara1 and Marina Aloi1 (1) Pediatric Gastroenterology and Liver Unit,…
Complementary and Alternative Therapies
Biologically based therapy Year Indication Subjects Comparator Duration Response on CAM (%) Response on comparator (%) Author, Ref I. Herbal therapies: Aloe vera 2004 UC 44 Placebo 4 weeks 30…
Treatment of Acute Severe Ulcerative Colitis
Fig. 37.1 Sigmoid colon: Diffuse inflammation with loss of vascular pattern and ulceration, typical of the pattern seen in ulcerative colitis He continued to do well, and maintenance infliximab therapy…
Medical Treatment of Perianal Crohn’s Disease Fistulae
Author, year N Drug, dose Rx time Response drug Response placebo p-value Willoughby et al., 1971 [75] 3 AZA, 2 mg/kg/day 24 weeks 0/2 (0%) 0/1 (0%) NR Rhodes et…
