Inflammatory and Other Nonneoplastic Disorders of the Pancreas

Mar 31, 2019 by in GENERAL Comments Off on Inflammatory and Other Nonneoplastic Disorders of the Pancreas

Chapter Outline Introduction Acute Pancreatitis Chronic Pancreatitis Confirming a Diagnosis Alcoholic Pancreatitis Genetics of Pancreatitis Trypsinogen Mutations SPINK1 Mutations CFTR Mutations Hereditary Pancreatitis Pancreatic Divisum Autoimmune Pancreatitis Paraduodenal Pancreatitis (“Groove”…

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Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract

Mar 31, 2019 by in GENERAL Comments Off on Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract

Chapter Outline Introduction Sampling Gallbladder Specimens Gallbladder Tumoral Intraepithelial Neoplasms Intracholecystic Papillary-Tubular Neoplasms Mucinous Cystic Neoplasms Nontumoral Preinvasive Lesions: Dysplasia and Carcinoma In Situ Adenocarcinoma Papillary Carcinomas Mucinous Carcinoma Adenosquamous…

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Algorithmic Approach to Diagnosis of Liver Disorders

Mar 31, 2019 by in GENERAL Comments Off on Algorithmic Approach to Diagnosis of Liver Disorders

Chapter Outline Introduction Helpful Diagnostic Tips Identification of Major Pattern of Injury Predominantly Portal Inflammation Ductular Reaction Steatosis Prominent Lobular Inflammation Pigments in the Liver Fibrosis (and Cirrhosis) Diagnosis of…

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Liver Pathology in Pregnancy

Mar 31, 2019 by in GENERAL Comments Off on Liver Pathology in Pregnancy

Chapter Outline Introduction Laboratory and Histologic Changes of the Liver in Pregnancy Intrahepatic Cholestasis of Pregnancy Acute Fatty Liver of Pregnancy Preeclampsia and Eclampsia HELLP Syndrome Hepatic Rupture Hyperemesis Gravidarum…

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Tumors of Major and Minor Ampulla

Mar 31, 2019 by in GENERAL Comments Off on Tumors of Major and Minor Ampulla

Chapter Outline Introduction Anatomic and Histologic Considerations Classification of Ampullary Tumors Preinvasive Neoplasms Adenomas of the Ampullary Duodenum Intraampullary Papillary-Tubular Neoplasms Flat Dysplasia Invasive Adenocarcinomas Uncommon Carcinomas Staging of Ampullary…

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Liver Tissue Processing and Normal Histology

Mar 31, 2019 by in GENERAL Comments Off on Liver Tissue Processing and Normal Histology

Chapter Outline Liver Biopsy Specimens Specimen Handling Normal Microanatomy of the Liver Interpretation of Liver Biopsies Liver Resection Specimens Partial Hepatectomies Liver Explants Routine and Special Stains Immunohistochemistry Electron Microscopy…

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Autoimmune and Chronic Cholestatic Disorders of the Liver

Mar 31, 2019 by in GENERAL Comments Off on Autoimmune and Chronic Cholestatic Disorders of the Liver

Chapter Outline Introduction Autoimmune Hepatitis Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Overlap Syndromes Immunoglobulin G4–Associated Cholangitis Secondary Sclerosing Cholangitis Ischemic Cholangitis Miscellaneous Ductopenic Syndromes Obstructive Cholangitis Introduction The three most…

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Inflammatory Disorders of the Large Intestine

Mar 31, 2019 by in GENERAL Comments Off on Inflammatory Disorders of the Large Intestine

Chapter Outline Approach to Evaluating Colitis Normal Versus Abnormal Acute Versus Chronic Colitis Ulcerative Colitis Crohn’s Colitis Chronic Inflammatory Bowel Disease, Unknown Type (Indeterminate Colitis) Dysplasia in Inflammatory Bowel Disease…

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Molecular Pathogenesis and Diagnostics of Hepatocellular Tumors

Mar 31, 2019 by in GENERAL Comments Off on Molecular Pathogenesis and Diagnostics of Hepatocellular Tumors

Chapter Outline Introduction Benign Hepatocellular Tumors Focal Nodular Hyperplasia Hepatocellular Adenoma Use of Molecular Diagnostics Hepatocellular Carcinoma and Its Precursors Molecular Changes in Hepatocarcinogenesis Precancerous Lesions in Hepatocarcinogenesis Early Hepatocellular…

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Mesenchymal Tumors of the Gastrointestinal Tract

Mar 31, 2019 by in GENERAL Comments Off on Mesenchymal Tumors of the Gastrointestinal Tract

Chapter Outline Introduction Gastrointestinal Stromal Tumors (GISTs) GIST Syndromes and Succinate Dehydrogenase–Deficient GISTs Tumors of Neural Origin Schwannoma Gangliocytic Paraganglioma Ganglioneuroma and Ganglioneuromatosis Mucosal Perineurioma Mucosal Schwann Cell Hamartoma Granular…

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