Crohn’s disease (CD) is a chronic inflammatory disease that confers a higher risk of cancer than in the general population. New, large, population-based studies in the past decade show that…
Edward V. Loftus Jr, MD, Editor It has been over 100 years since the Scottish surgeon Sir T. Kennedy Dalziel described several cases of “chronic interstitial enteritis” resulting in diarrhea,…
Crohn’s disease is a chronic inflammatory disorder that can progress to obstructive and penetrating complications. Although clinical symptoms are an important component of therapy, they correlate poorly with objective measures…
Individuals with a genetic predisposition to Crohn’s disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of…
Crohn’s disease (CD) is a chronic condition that can result in significant morbidity and disability. By studying the association between demographics and initial clinical features and subsequent natural history, one…
Since the discovery of the first Crohn’s disease (CD) gene NOD2 in 2001, 140 genetic loci have been found in whites using high-throughput genome-wide association studies. Several genes influence the…
Fig. 3.1 Sclerosing mesenteritis. (a) On low-power view, sclerosing mesenteritis consists of a diffuse replacement of the resident mesenteric soft tissues (mostly adipose tissue) by a dense fibrous tissue (arrow)…
Fig. 12.1 Skin biopsy of an overlap case of histiocytosis (Langerhans cell histiocytosis, LCH, and Erdheim-Chester disease, ECD). (a) LCH, Langerhans cells infiltrating the superficial dermal and the epidermal layers…
Characteristic Durst [13] Emory [15] Akram [1] Year of publication 1977 1997 2007 Study design Cumulative literature dataa Retrospective, single-centerb Retrospective, single-centerc Study period 1955–1972 1970–1993 1982–2005 No. of cases…
Study (location) Year GBCA exposure Cases of GIF/GBCA exposed patients with renal disease Notes Marckmann (Denmark) 2006 Gadodiamide 13/370 (3.5 %) Retrospective chart review: strong association of gadodiamide exposure with…
