The Liver in Systemic Disease and Pregnancy
CHAPTER 15 The Liver in Systemic Disease and Pregnancy Introduction Liver biopsies are often obtained to evaluate abnormalities of liver function tests in patients with known or suspected systemic disease…
Biliary Disease
CHAPTER 5 Biliary Disease Introduction There are many sites along the biliary tree where bile flow may be interrupted, from the bile canaliculi and smallest intrahepatic ducts to the large…
The Liver in Organ Transplantation
CHAPTER 16 The Liver in Organ Transplantation Introduction The pathologist is often asked to examine liver biopsies obtained to evaluate liver dysfunction in transplant patients, including recipients of liver, renal…
Childhood Liver Disease and Metabolic Disorders
CHAPTER 13 Childhood Liver Disease and Metabolic Disorders Introduction Paediatric liver biopsies present a unique set of diagnostic problems for the pathologist, many of which become clinically apparent in the…
Chronic Hepatitis
CHAPTER 9 Chronic Hepatitis Definition and causes Chronic hepatitis is a common reason for persistently abnormal liver function tests1 and forms the background for the development of much cirrhosis2 and…
Disturbances of Copper and Iron Metabolism
CHAPTER 14 Disturbances of Copper and Iron Metabolism Wilson’s disease (hepatolenticular degeneration) Wilson’s disease is an autosomal recessive disorder due to mutations in the gene ATP7B for copper-transporting ATPase located…
Steatosis, Steatohepatitis and Related Conditions
CHAPTER 7 Steatosis, Steatohepatitis and Related Conditions Steatosis Steatosis (fatty change, fatty liver) is the accumulation of abnormal amounts of lipid in hepatocytes. Most steatosis is of the macrovesicular type,…
Acute Viral Hepatitis
CHAPTER 6 Acute Viral Hepatitis Introduction Acute hepatitis is not usually an indication for liver biopsy. There are, however, at least three reasons why pathologists sometimes receive liver biopsy samples…
Vascular Disorders
CHAPTER 12 Vascular Disorders The hepatic arteries The effects of occlusion of hepatic artery branches are unpredictable because of the liver’s double blood supply and variable collateral flow. Potential effects…
