Hepatitis B (Hepatology 2007;45:507-39. Clin Gastroenterol Hepatol. 2006;4:936-62; Hepatology. 2004;39:1-5) DEFINITION: A hepatotrophic virus; the liver is the primary site of infection, replication and cellular damage Chronic hepatitis: presence of…
Hepatitis A, D, E HEPATITIS A Definition: A hepatotrophic virus; the liver is the primary site of infection, replication and cellular damage Epidemiology: Undeveloped countries: Africa, Asia, etc. In U.S.,…
Hemochromatosis & Iron Overload (Hepatology 2001;33:1321-28) DEFINITIONS: Hereditary Hemochromatosis (HH): Autosomal recessive inherited disorder of iron overload Increased iron absorption from the gut, with preferential deposition of iron in liver…
Drug & Toxic Induced Liver Disease DEFINITION: More than 600 medicines have been reported to cause liver injury; Two most common: Acetaminophen and Alcohol; See also Liver- Alcoholic Liver Disease…
Congenital Hepatic Fibrosis DEFINITION: Fibrous enlargement of the portal tracts with abnormally shaped bile ducts and no cirrhosis EPIDEMIOLOGY: Autosomal recessive; Most commonly presents in childhood, but can be diagnosed…
Cirrhosis & Encephalopathy DEFINITION: Fibrosis and nodular regeneration resulting from hepatocellular injury EPIDEMIOLOGY: Cirrhosis and chronic liver disease accounted for more than 25,000 deaths and 375,000 hospitalizations in 1998 ETIOLOGIES:…
Bacterial Peritonitis (Hepatology 2000;32:142-53) Type Ascites Cell Count/mm3 Ascites Culture Sterile <250 polys − SBP >250 polys + (one organism) (CNNA) Culture-neg Neutrocytic ascites >250 polys − (NNBA) Non-neutrocytic bacterascites…
Autoimmune Hepatitis (Hepatology 2002;36:479-97) DEFINITION: Autoimmune Hepatitis (AIH) is an unresolving inflammation of liver, unknown cause: Characterized by interface hepatitis (histology), autoantibodies & hypergammaglobulinemia (serum) Types of AIH: Features Type…
Ascites & Portal Hypertension (Hepatology 2004;39:1-16) DEFINITION: Accumulation of fluid within the peritoneal cavity EPIDEMIOLOGY: More than 30% of patients with ascites have an ascitic fluid infection at the time…
