Fig. 25.1 Algorithm of PE diagnosis and management (adapted from Jannini et al. 2010 [79]). Note that the possibility of another comorbid sexual dysfunction should be ruled out first. When risk…
Fig. 3.1 Frontal section at the level of the prostatic and proximal penile urethra 3.2.1 Organs of Emission The epididymis is a long coiled tube of epithelial cells covered by connective…
Fig. 20.1 Molecular structure of dapoxetine: (+)-(S)-N,N-dimethyl-(α)-[2(1naphthalenyloxy)ethyl]-benzenemethanamine hydrochloride 20.3.1 Pharmacokinetics and Metabolism Dapoxetine undergoes rapid absorption and elimination resulting in minimal accumulation and has dose-proportional pharmacokinetics, which are unaffected by multiple…
Fig. 19.1 Mechanism 1, 2 and 3 leading to homeostasis of the central serotonergic neuron [47] This complex feedback mechanism in the central serotonergic system is meant to sustain homeostasis [47]….
Variable Lifelong premature ejaculation Acquired premature ejaculation Natural variable premature ejaculation Premature-like ejaculatory dysfunction IELT Very short IELT (<1–1.5 min) (Very) short IELT (<1.5–2 min) Normal IELT (3–8 min) Normal or long IELT…
Fig. 6.1 Epidemiological stopwatch study in general male population in five countries [12] Fig. 6.2 Epidemiological blinded-stopwatch study in general male population in five countries [13] 6.5 Neurobiology and Genetics of the…
Associated with sustained hormone overproduction (hyperthyroidism) Graves disease Toxic multinodular goiter Toxic adenoma Iodine-induced (jodbasedow) TSH secreting pituitary adenoma Not associated with hyperthyroidism Thyrotoxicosis factitia Subacute thyroiditis Chronic thyroiditis with…
Fig. 21.1 Management algorithm for PE modified from Lue et al. [2] Delayed ejaculation is a common side-effect of many psychotropic or antidepressant drugs, in particular of the serotoninergic tricyclic antidepressant…
Fig. 14.1 Anatomy of the penis and prepuce 14.2.1.2 Receptors and Nerve Endings Numerous specialized nerve endings have been identified in the penis and prepuce (Table 14.1). The most numerous nerve terminals…
Authors Postulated etiology and pathogenesis of PE Advocated treatment of PE Karl Abraham (1917) PE is a neurosis, linked to unconscious conflicts Psycho-analysis and psycho-analytic therapy Bernhard Schapiro (1943) PE…
