The Amyloidoses
Amyloid type Protein Abbreviation Organ involvement Comment Immunoglobulin light chain Monoclonal Ig light chain AL Kidney, liver, heart, GI tract, peripheral and autonomic nerves, soft tissues Acquired plasma cell dyscrasia…
Amyloid type Protein Abbreviation Organ involvement Comment Immunoglobulin light chain Monoclonal Ig light chain AL Kidney, liver, heart, GI tract, peripheral and autonomic nerves, soft tissues Acquired plasma cell dyscrasia…
Fig. 13.1 Immunofluorescence microscopy with antisera to kappa light chain shows prominent staining of tubular basement membranes (TBM) in a linear pattern. Staining can also be seen in the glomerulus…
Fig. 4.1 Risk of chemotherapy-associated AKI depends on the interactions among patient, drug, and kidney specific risk factors. ADE adverse drug effects, AKI acute kidney injury, GFR glomerular filtration rate…
Type of conditioning Donor relationship CNI exposure Risk of GVHD Risk of AKI (%) Risk of AKI requiring RRT (%) Risk of Mortality if RRT (%) Myeloablative Allogeneic High Very…
Fig. 9.1 Case presentation: MRI, coronal section, revealing heterogeneous right renal mass Basic Epidemiology and Risk Factors of Kidney Cancer Kidney cancer or RCC is the eighth most common cancer…
Fig. 15.1 Electrolyte abnormalities associated with obstruction and post obstruction Case # 1 Follow-Up and Discussion The patient presented with newly diagnosed lymphoma as seen in the CT scan shows…
Laboratory TLS: two or more of (within − 3 to + 7 days relative to treatment) Clinical symptoms (any of) Clinical I Clinical II Clinical III Clinical IV Uric acid >8 mg/dL (476 µmol/L)…
Fig. 3.1 Membranous Nephropathy (original magnification ×600, trichrome stain). Glomerulus displaying membranous features with fuchsinophilic subepithelial deposits. (Source: Jhaveri KD, Shah HH, Calderon K, Campenot ES, Radhakrishnan J. Glomerular diseases seen…
Fig. 7.1 The principal participants in normal bone remodelling include three cell types (bone marrow stromal cells, osteoblasts [OB], and osteoclasts [OC]) and three proteins (receptor activator of nuclear factor…
Drug CrCl 60–46 mL/min CrCl 45–30 mL/min CrCl 29–10 mL/min Dialysis Nephrotoxicity presentation/comments Arsenic trioxide No adjustment needed No adjustment needed Drug exposure may be higher, monitor for toxicity, and lower doses may…