The Amyloidoses

Jul 17, 2017 by in NEPHROLOGY Comments Off on The Amyloidoses

Amyloid type Protein Abbreviation Organ involvement Comment Immunoglobulin light chain Monoclonal Ig light chain AL Kidney, liver, heart, GI tract, peripheral and autonomic nerves, soft tissues Acquired plasma cell dyscrasia…

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Dysproteinemias and Kidney Disease

Jul 17, 2017 by in NEPHROLOGY Comments Off on Dysproteinemias and Kidney Disease

Fig. 13.1 Immunofluorescence microscopy with antisera to kappa light chain shows prominent staining of tubular basement membranes (TBM) in a linear pattern. Staining can also be seen in the glomerulus…

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Nephrotoxicity of Chemotherapy Agents

Jul 17, 2017 by in NEPHROLOGY Comments Off on Nephrotoxicity of Chemotherapy Agents

Fig. 4.1 Risk of chemotherapy-associated AKI depends on the interactions among patient, drug, and kidney specific risk factors. ADE adverse drug effects, AKI acute kidney injury, GFR glomerular filtration rate…

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Obstructive Renal Disease in Cancer Patients

Jul 17, 2017 by in NEPHROLOGY Comments Off on Obstructive Renal Disease in Cancer Patients

Fig. 15.1 Electrolyte abnormalities associated with obstruction and post obstruction Case # 1 Follow-Up and Discussion The patient presented with newly diagnosed lymphoma as seen in the CT scan shows…

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Tumor Lysis Syndrome

Jul 17, 2017 by in NEPHROLOGY Comments Off on Tumor Lysis Syndrome

Laboratory TLS: two or more of (within − 3 to + 7 days relative to treatment) Clinical symptoms (any of) Clinical I Clinical II Clinical III Clinical IV Uric acid  >8 mg/dL (476 µmol/L)…

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Electrolyte Disorders in Cancer Patients

Jul 17, 2017 by in NEPHROLOGY Comments Off on Electrolyte Disorders in Cancer Patients

Fig. 7.1 The principal participants in normal bone remodelling include three cell types (bone marrow stromal cells, osteoblasts [OB], and osteoclasts [OC]) and three proteins (receptor activator of nuclear factor…

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Rational Dosing of Chemotherapy in Patients with Kidney Failure

Jul 17, 2017 by in NEPHROLOGY Comments Off on Rational Dosing of Chemotherapy in Patients with Kidney Failure

Drug CrCl 60–46 mL/min CrCl 45–30 mL/min CrCl 29–10 mL/min Dialysis Nephrotoxicity presentation/comments Arsenic trioxide No adjustment needed No adjustment needed Drug exposure may be higher, monitor for toxicity, and lower doses may…

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