Fig. 11.1 Membranous nephropathy. (a–b) Light microscopy showing thickened glomerular basement with pin holes and spikes ((a) periodic acid-Schiff stain, (b) silver methenamine stain, both 40×). (c) Immunofluorescence microscopy showing…
Fig. 3.1 Pathobiology of circulating Angptl4 in nephrotic syndrome (From [21]). Diagram representing the production of circulating Angptl4 protein and its biological effects. The circulating, sialylated form of Angptl4 is…
Fig. 2.1 Electron micrographs of glomerular capillary segments from sections of rat kidney following infusion in vivo with either Hpx (a) or heat-inactivated Hpx (HI-Hpx) (b). The tissue samples were…
Fig. 6.1 Current pathophysiological hypotheses involved in relapsing idiopathic nephrotic syndrome (INS). Clinical and experimental observations suggest that lymphocytes and podocyte disturbances are two sides of relapsing INS. Besides T-lymphocyte…
Fig. 12.1 Results of two-dimensional electrophoresis and immunoblot demonstrating that circulating albumin in children migrates in the basic range of pH (lane 1–4) (Debiec et al. [18]) Fig. 12.2 Expression…
Authors N IL-1 IL-2 sIL-2R IL-4 IL-5 IL-7 IL-8 IL-10 IL-12 IL-13 IL-18 IFN-γ TNF-α VEGF MCD Garin [89] 12 ↑ Cho [76] 19? ↑ ↔ Wada [110] 3 ND …
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_4 4. Co-stimulatory Molecule CD80 (B7.1) in MCNS Michiko Shimada1 , Takuji Ishimoto2 and Richard J. Johnson3 (1) Division of Cardiology and Nephrology, Hirosaki University Graduate…
Ref. TNFα IL2 IL1β IL4 IL6 IL8 IL10 IL12 IL13 IFN-γ Surany et al. [14] Serum + Serum − Serum − − Garin et al. [19] Cell mRNA + Serum…
Fig. 13.1 Signalling pathways targeted by different drugs in podocytes. The glomerular capillary wall comprises of three components: glomerular endothelial cells, GBM (glomerular basement membrane) and podocytes. With its unique…
35. Savin VJ, McCarthy ET, Sharma R, Charba D, Sharma M. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl Res. 2008;151:288–92. doi:10.1016/j.trsl.2008.04.001.PubMed 36. McCarthy ET,…
