Clinical trials ACT1/ACT2 ULTRA1/ULTRA2 PURSUIT-SC Placebo (n = 121/123) IFX 5 mg/kg (n = 121/121) IFX 10 mg/kg (n = 122/120) Placebo (n = 130/246) ADA 80/40 (n = 130/–) ADA 160/80 (n = 130/248) Placebo (n = 331) GLM 100/50 (n = 72) GLM 200/100…
Fig. 15.1 Mucosal healing 14 weeks after introduction of infliximab. Endoscopic images of the sigmoid at baseline (upper panel) and at week 14 (lower panel) in a patient receiving infliximab…
© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_14 14. Tacrolimus, Sirolimus, and Mycophenolate Mofetil Andreas Fischer1 and Daniel C. Baumgart1 (1) Department of Medicine, Division of Gastroenterology and Hepatology Charité Medical…
Fig. 12.1 Azathioprine (AZA) metabolism. XO xanthine oxidase, 6-TU 6-thiouric acid, and 6-TIMP 6-thioinosine monophosphate An apparent genetic polymorphism has been observed in TPMT activity in both the Caucasian and…
Fig. 7.1 Proposed metabolic pathway of 5-ASA after oral administration. The shaded area (large intestine) indicates the site of topical action. Unformulated 5-ASA is absorbed rapidly from the small intestine,…
and Javier P. Gisbert1 (1) Department of Gastroenterology, La Princesa University Hospital, Diego de Leon 62, Madrid, 28006, Spain Javier P. Gisbert Email: javier.p.gisbert@gmail.com KeywordsThiopurinesAzathioprineMercaptopurineMethotrexateUlcerative colitis Introduction Ulcerative colitis (UC) is a…
Fig. 9.1 The mechanism of action of corticosteroids on the immune system Although corticosteroids can suppress inflammatory genes, they also inhibit the transcription of other genes, including osteocalcin, keratin, proopiomelanocortin…
Induction therapy [1, 2] Maintenance therapy Mild • Oral 5-ASA • Topical 5-ASA • Topical steroid • Oral 5-ASA, with or without topical 5-ASA Moderate • Oral 5-ASA •…
Fig. 5.1 Variable appearances of mucosa in ulcerative colitis In an effort to quantify the degree of inflammation, a number of different clinical, endoscopic, and composite scoring systems have been…
7. Crohn BB. An historic note on ulcerative colitis. Gastroenterology. 1962;42:366–7.PubMed 8. Bassler A. Ulcerative colitis. Interstate Med J. 1913;20:705–6. 9. Brown J. The value of complete physiological rest of…
