Miscellaneous Lesions Duodenal pseudolipomatosis histologically resembles pseudolipomatosis in the colon and stomach. Numerous clear, rounded, PAS-negative, variably sized vacuoles are present in the lamina propria. These vacuoles can cause expansion…
MÜllerian Lesions Müllerian lesions may present as mural small intestinal masses. These include endometriosis, which is discussed in detail in Chapter 13, and endocervicosis. Endocervicosis is the presence of benign…
Lymphatic Lesions Lymphangiectasia Intestinal lymphangiectasia is a rare congenital obstructive defect of the lymphatics primarily affecting children and young adults. It is characterized by protein-losing enteropathy, hypoproteinemia, edema, lymphocytopenia, malabsorption,…
Vascular Lesions Vascular lesions include telangiectasias, malformations, dysplasias, and neoplastic proliferations. In this chapter, we will cover malformations and telangiectasias; neoplasms are covered in Chapter 19 and angiodysplasia is covered…
Ischemic Enteritis When the blood supply to a tissue is interrupted, a sequence of chemical events leads to cellular dysfunction, edema, and ultimately cell death. Tissue anoxia results in anaerobic…
Diseases Associated with Abnormal Deposits in the Tissues Hemochromatosis Hereditary hemochromatosis (HH), an autosomal recessive disease, causes 1 in 7,000 hospital deaths and 1 in 20,000 annual hospital admissions (628)….
Cystic Fibrosis Cystic fibrosis (CF) is an autosomal recessive disorder that affects 1 in 100,000 to 200,000 live births. CF results from mutations in the gene encoding the cystic fibrosis…
Small Intestinal Lesions Resembling Graft Versus Host Disease Changes similar to those found in GVHD sometimes occur in immunosuppressed or immunodeficient patients, without transplants or transfusions. The lesion affects any…
Immunodeficiency Diseases Patients with immunodeficiency syndromes often present with chronic diarrhea, malabsorption, and other intestinal abnormalities, as well as with the effects of the immunodeficiency, particularly infections. The immunodeficiency syndromes…
Graft Versus Host Disease GVHD is an immunologic disorder that results in severe gastrointestinal damage. It represents the response of immunocompetent donor cells to the histocompatibility antigens of the recipient….
