The prevalence of esophageal adenocarcinoma is increasing dramatically. Barrett’s esophagus remains the most well-established risk factor for the development of esophageal adenocarcinoma. There are multiple clinical, endoscopic, and pathologic factors…
Surveillance of Barrett’s esophagus for preventing death from esophageal adenocarcinoma is attractive and widely practiced. However, empirical evidence supporting its effectiveness is weak. Longer intervals between surveillance examinations are being…
There is substantial interest in identifying patients with premalignant conditions such as Barrett’s esophagus (BE), to improve outcomes of subjects with esophageal adenocarcinoma. However, there is limited consensus on the…
Central obesity is involved in the pathogenesis and progression of Barrett’s esophagus to esophageal adenocarcinoma. Involved are likely both mechanical and nonmechanical effects. Mechanical effects of increased abdominal fat cause…
Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), a disease with increasing burden in the Western world, especially in white men. Risk factors for BE include obesity, tobacco…
This article focuses on recent findings on the molecular mechanisms involved in esophageal columnar metaplasia. Signaling pathways and their downstream targets activate specific transcription factors leading to the expression of…
Gary W. Falk, MD, MS, Consulting Editor The incidence of esophageal adenocarcinoma continues to increase at an alarming rate in the Western world. While the prognosis for early esophageal adenocarcinoma…
Prasad G. Iyer, MD, MSc, FACG, FASGE, AGAF, Editor Navtej S. Buttar, MD, Editor Barrett’s esophagus (BE) is currently a field in rapid evolution. A number of well established paradigms…
Chemoprevention in Barrett’s esophagus is currently applied only in research settings. Identifying pathways that can be targeted by safe, pharmaceutical or natural compounds is key to expanding the scope of…
Esophageal adenocarcinoma (EAC) develops from Barrett’s esophagus (BE), wherein normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. BE can progress to low-…
