(a) Conditions favoring APN and increasing the clinical severity Age >65 years Diabetes Cancer Pregnancy Urinary tract obstruction Urinary tract anatomic/functional abnormalities Immunosuppression Broad antibiotic resistance Neurologic bladder Hospital-acquired infection Urethral catheter,…
Fig. 1.1 An enlarged glomerulus shows diffuse endocapillary hypercellularity with numerous neutrophils and closure of all glomerular capillaries. The glomerulus is increased in size and cellularity, H&E, ×200 Fig. 1.2 Acute diffuse…
Primary TMA syndromes Hereditary disorders ADAMTS13 deficiency-mediated TMA (also called TTP) Complement-mediated TMA Coagulation-mediated TMA Acquired disorders ADAMTS13 deficiency-mediated TMA (also called TTP) Shiga toxin-mediated TMA (also called ST-HUS) Drug-mediated…
Fig. 4.1 Two glomeruli with segmental necrosis and one with a cellular crescent (glomerulus on the left) in a 62-year-old male with crescentic glomerulonephritis associated with mitral valve Streptococcus viridans infective…
Clinicopathologic features n % Age (years) 55 ± 12.1 (21–91) Ethnicity Caucasian 74 95 African American 3 3.8 Asian 1 1.2 Gender Males 61 78 Females 17 22 Diabetes mellitus 32 41…
Fig. 3.1 Histological spectrum in infection-associated glomerulonephritis. a–c Infection-associated exudative glomerulonephritis with numerous infiltrating neutrophils is usually associated with acute presentation of nephritic syndrome (a H&E, ×400). The glomerular deposits are C3-dominant…
Fig. 8.1 Zonal pattern of inflammation is more common in pyelonephritis (as opposed to diffuse inflammation in acute rejection) in which inflamed areas of renal cortex are immediately juxtaposed to well-preserved…
APSGN SAGN Time of GN onset 1–4 weeks after infection has resolved During the course of active infection. Typically weeks to months after infection starts Pathogen species Group A β-hemolytic…
