Abbreviations AMR antibody-mediated rejection ATN acute tubular necrosis CAN chronic allograft nephropathy CMV cytomegalovirus CNI calcineurin inhibitor CNIT calcineurin inhibitor toxicity DGF delayed graft function DSA donor-specific antibody EM electron…
Acknowledgments Original work by the authors was funded by the NIH (grant 1U01AI070107) and National Health and Medical Research Council of Australia. Karen Keung is a recipient of the Jacquot…
Naturally occurring antibodies against blood group antigens and acquired alloantibodies against donor human leukocyte antigens (HLAs; secondary to a prior kidney transplant, blood transfusions, or pregnancy) may pose major barriers…
It is a favorite assertion of the authors that clinical transplantation is an excellent example of “medical ethics in practice.” Perhaps this is best demonstrated by the processes of organ…
Introduction There are far more eligible kidney transplant candidates worldwide than there are organs available. Kidney exchange, also referred to as paired kidney donation, has become strongly established over the…
Acknowledgments The work from the authors’ own laboratories described in this review was supported by grants from The Wellcome Trust, Medical Research Council, British Heart Foundation, The Deutsche Forschungsgemeinschaft, and…
Small Molecules Leflunomide and Malononitrilamides Leflunomide, initially developed as an agriculture herbicide, was explored as an immunosuppressant because of its ability to inhibit the enzyme dihydroorotate dehydrogenase. The potential of…
A successful long-term outcome for a new kidney transplant recipient depends on the early perioperative management and course after surgery. Important factors affecting long-term outcome include the occurrence of delayed…
Renal transplantation is the preferred treatment for most end-stage renal diseases. Transplantation’s success, however, has been counterbalanced, by its dependence on immunosuppressive drugs with their related infectious, metabolic, and malignant…
Although the improved outcomes over the past 60+ years in kidney transplantation have been related to a number of factors, the effect of immunosuppression has perhaps been the most significant….
