Parameters Yes No Comment Validity Is the randomization procedure well described? +1  The protocol was fully described in a prior publication [5] 2 × 2 factorial design aimed at investigating: Impact of…

Parameters Yes No Comment Validity Is the Randomization Procedure well described? +1  Central process, block randomization in which block size also varied randomly, with stratification for center and diabetic status….

Parameters Yes No Comment Validity Is the Randomization Procedure well described?  −1 Method of randomization was not clearly described Group stratification prior to randomization was explained in detail Double blinded?…

Study Induction or maintenance Agents used Key comments RAVE Induction Rituximab vs. cyclophosphamide Rituximab was not inferior to cyclophosphamide in induction of remission and may be more effective than cyclophosphamide…

Parameters Yes No Comment Validity Is the Randomization Procedure well described? +1  1:1 to acetylcysteine or placebo generated by permuted blocks of variable size and stratified by site Double blinded?…

Parameters Yes No Comment Validity Is the Randomization Procedure well described? +1  A computer-generated randomization method was used. Baseline variables were well balanced without any significant difference Double blinded? +2  …

Parameters Yes No Comment Validity Is the randomization procedure well described? +1  It was well described. Baseline characteristics were well balanced Double blinded?  −1 Open label Is the sample size…

Fig. 1.1 Flow-chart summary of literature search and study selection We found 22 RCTs to date (11 June 2014) on ADPKD management (Table 1.1). Most (16 of 22) of the…