Fig. 13.1 Signalling pathways targeted by different drugs in podocytes. The glomerular capillary wall comprises of three components: glomerular endothelial cells, GBM (glomerular basement membrane) and podocytes. With its unique…
35. Savin VJ, McCarthy ET, Sharma R, Charba D, Sharma M. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl Res. 2008;151:288–92. doi:10.1016/j.trsl.2008.04.001.PubMed 36. McCarthy ET,…
Fig. 5.1 Protein synthesis system: Protein production is regulated and orchestrated by two signaling pathways: mTORC1 and UPR. Both pathways require ATP as an energetic currency, in which mTORC1 activation…
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_1 1. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome Kazunari Kaneko1 (1) Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi,…
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_9 9. Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) in Focal Segmental Glomerulosclerosis Jochen Reiser1 and Nada Alachkar2 (1) Department of Medicine, Rush University…
Parameters Yes No Comment Validity Is the randomization procedure well described? +1 142 on cyclosporine + steroids versus 149 best therapy at the time mostly azathioprine + steroids Double blinded? −2 Unblinded trial, thus…
Parameters Yes No Comment Validity Is the Randomization Procedurewell described? +1 Randomization was by means of centrally produced, computer-generated therapy allocations in sealed, opaque envelopes which were opened in sequence…
Parameters Yes No Comment Validity Is the Randomization Procedure well described? +1 Yes. Permuted-block design stratified according to center Double blinded? −2 No Is the sample size calculation described/adequate? +3 …
Parameters Yes No Comment Validity Is the randomization procedure well described? −1 Double blinded? −2 Is the sample size calculation described/adequate? −3 Does it have a hard primary endpoint? …
Parameters Yes No Comment Validity Is the randomization procedure well described? +1 Random from masked card sequence Double blinded? −2 Open label Is the sample size calculation described/adequate? −3…
