Cessation of Biologics: Can It Be Done?
Authors Number of participants (n) Study design Relapse rate Significant predictors of relapse Predictors evaluated but not found to be significant Recapture rate CD Brooks et al. [52] 86…
GASTROENTEROLOGY
Use of Biologics in Crohn’s Disease and Ulcerative Colitis Prior to Surgery and Perioperative Risks
Study Infliximab (n) Non-infliximab (n) Total (n) Odds ratio Appau et al. [8] 60 329 389 2.93 (1.63–5.27) Canedo et al. [11] 65 160 225 1.19 (0.58–2.42) Kasparek et al….
Antitumor Necrosis Factor Agents in Crohn’s Disease
Fig. 3.1 Induction of remission with corresponding placebo rates from seminal clinical trials for each anti-TNF (note: trials had different inclusion criteria and end points and thus while presented on…
Mechanism of Action and Pharmacokinetics of Biologics
Infliximab Adalimumab Certolizumab Golimumab CT-P13 ABP501 sTNF binding Y Y Y Y Y Y mTNF binding Y Y Y Y Y Y mTNF reverse signaling Y Y ? Y…
Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease
© Springer International Publishing AG 2018Adam S. Cheifetz and Joseph D. Feuerstein (eds.)Treatment of Inflammatory Bowel Disease with Biologics https://doi.org/10.1007/978-3-319-60276-9_4 4. Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease David I. Fudman1 and Sarah N. Flier1 …
Biologics in Pregnancy and Breastfeeding
Term Definition Adverse pregnanc y outcomes Spontaneous abortion/miscarriage Induced abortion Preterm birth (delivery <37 weeks of gestation) Small for gestational age (birth weight <10th percentile for gestational age) Stillbirth Ectopic…
Antitumor Necrosis Factor Agents in Ulcerative Colitis
Anti-TNFα medication Authors, date Study summary Study population, sample size Dosing information Clinical response Clinical remission and mucosal improvement Infli ximab Rutgeerts et al. [15] Induction (ACT 1) 364 TNF-naïve…
Colonoscopic Polypectomy: Punch, Snaring and EMR
Fig. 2.1 Estimating polyp siz e using biopsy forceps. The biopsy forceps have jaws with 2.5 mm in diameter, which open to a width of 7 mm For the successful…
Management of Colorectal Bleeding
Fig. 5.1 Immediate bleeding after polypectomy can be easily controlled by coagulation Fig. 5.2 (a) Active bleeding site covered with blood clots, (b) bleeding control by clipping 5.1 APC (Argon…
Early Colorectal Cancer
Category Diagnosis 1 Negative for neoplasia 2 Indefinite for neoplasia 3 Mucosal low grade neoplasia Low grade adenoma Low grade dysplasia 4 Mucosal high grade neoplasia 4–1 High grade adenoma/dysplasia…
