Abstract Confocal laser endomicroscopy (CLE) provides real-time microscopic imaging within the esophagus after administration of fluorescein. It permits immediate diagnosis of Barrett’s esophagus and associated intraepithelial neoplasia (dysplasia). Multiple trials…

Abstract The incidence of adenocarcinoma of the esophagus is increasing more rapidly than any other type of carcinoma in the United States. Almost 100% of cases occur in patients with…

Abstract It has been estimated that 5.6% of adults in the United States have Barrett’s esophagus (BE). The metaplastic columnar mucosa of BE can silently evolve into adenocarcinoma and thus…

Abstract Barrett’s esophagus is a condition in which normal stratified squamous epithelium of the esophagus is replaced with columnar epithelium. It is the primary precursor lesion for esophageal adenocarcinoma and…

Abstract This chapter provides details regarding the normal anatomy and histology of gastroesophageal junction along with histologic features of Barrett’s esophagus (BE). In addition, the clinical and pathologic aspects of…

Abstract Esophageal adenocarcinoma (EAC) is a very heterogeneous disease and despite rapid advances in molecular technology, including sequencing the major driver mutations in the progression of its precursor, Barrett’s esophagus…

Abstract Barrett’s esophagus (BE) is an acquired condition associated with severe gastroesophageal reflux disease (GERD) and has a malignant predisposition. The overall prevalence of BE in general population varies between…

Abstract Barrett’s esophagus (BE) is the presence of metaplastic columnar epithelium in the lower portion of the esophagus, which is normally lined with stratified squamous epithelium. The main cause of…