Low-risk ERC High-risk ERC Absolute factors Morphology Polypoid Ulcerated Sessile Flat raised Tumour grade G1–G2 G3–G4/signet ring Depth of invasion Haggitt 1–3 Haggitt 4 pT1sm1 pT1sm2–3 Lympho-vascular invasion No…

© Springer International Publishing Switzerland 2015Gunnar Baatrup (ed.)Multidisciplinary Treatment of Colorectal Cancer10.1007/978-3-319-06142-9_1 1. Organizing the Multidisciplinary Team Gunnar Baatrup1, 2   (1) Institute of Regional Health Science, University of Southern Denmark, Svendborg, Denmark (2) Department of…

21. Quirke P, Dixon MF, Durdey P, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Lancet. 1986;1:996–8.CrossRef 22. Heald RJ, Husband EM, Ryall RDH. The mesorectum…

Authors No. of pts RT dose Gy/fractions/ days T2 Chemo Procedure cCR No failing Local failure Habr-Gama et al. [24] 118 50.4/28/38 Yes Bolus FUFA No surgery 32 % 8/30…

Fig. 13.1 The metabolism of fluoropyrimidines (Adapted from Longley et al. [3]) For many years, the best administration schedule for FU has been debated, and many efforts have been made…

© Springer International Publishing Switzerland 2015Gunnar Baatrup (ed.)Multidisciplinary Treatment of Colorectal Cancer10.1007/978-3-319-06142-9_12 12. Introduction to Oncology Per Pfeiffer1   (1) Department of Oncology, Odense University Hospital, Sdr Boulevard 29, Odense, DK – 5000, Denmark    …

Fatigue 0 None 1 Increased but not altering normal activities 2 Moderate, difficulty performing some activities 3 Severe, cannot perform some activities 4 Bedridden or disabling Nausea 0 None 1…

Fig. 6.1 Tumour cell migration within a vein (V1) and tumour cell invasion in a lymphatic vessel (L1) Independent from this, it was documented that the proportion of ‘high-risk’ tumours…

TNM Stage Extension to Tis N0 M0 0 Carcinoma in situ: intraepithelial or invasion of lamina propria T1 N0 M0 I Submucosa T2 N0 M0 I Muscularis propria T3 N0…