There is substantial interest in identifying patients with premalignant conditions such as Barrett’s esophagus (BE), to improve outcomes of subjects with esophageal adenocarcinoma. However, there is limited consensus on the…

Surveillance of Barrett’s esophagus for preventing death from esophageal adenocarcinoma is attractive and widely practiced. However, empirical evidence supporting its effectiveness is weak. Longer intervals between surveillance examinations are being…

Central obesity is involved in the pathogenesis and progression of Barrett’s esophagus to esophageal adenocarcinoma. Involved are likely both mechanical and nonmechanical effects. Mechanical effects of increased abdominal fat cause…

Barrett’s esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), a disease with increasing burden in the Western world, especially in white men. Risk factors for BE include obesity, tobacco…

This article focuses on recent findings on the molecular mechanisms involved in esophageal columnar metaplasia. Signaling pathways and their downstream targets activate specific transcription factors leading to the expression of…

Prasad G. Iyer, MD, MSc, FACG, FASGE, AGAF, Editor Navtej S. Buttar, MD, Editor Barrett’s esophagus (BE) is currently a field in rapid evolution. A number of well established paradigms…

Gary W. Falk, MD, MS, Consulting Editor The incidence of esophageal adenocarcinoma continues to increase at an alarming rate in the Western world. While the prognosis for early esophageal adenocarcinoma…

Helicobacter pylori infection contributes to a variety of gastric diseases. H pylori- associated gastric cancer is diagnosed in advanced stages, and a vaccine against H pylori is desirable in parts…

The purpose of this study was to elucidate the prevalence and effect of Helicobacter pylori infection in Japanese teenagers. The study subjects were students ages 16 to 17 from one…