T cell transfer Genetic Spontaneous Bacterial CD45RBhigh → RAG−/− (SB + C) WT → CD3εtg IL-2−/− IL-2Rα−/− IL-10−/− TCR−/− Gαi2−/− Mdr1a−/− TNFΔARE (SB) STAT3−/− STAT4 tg CD40L tg A20−/− TGFβ1−/−…
Antimicrobial Size (kDa) Antibacterial activity Cellular source α-Defensin 1–4 3.4 Gm+ and Gm− Neutrophils α-Defensin 5 3.6 Gm+ and Gm− Paneth cells α-Defensin 6 3.7 Self-assembles Forms protective nets Paneth…
Initial questions may include: Practical questions may include: What is Crohn’s disease or ulcerative colitis? Where is the nearest bathroom and will I have access to it? Is it contagious?…
Relative importance References Age < 17 years +++ [3, 110] Perianal disease ++ [8, 9] Need for steroids ++ [8, 9, 111] Ileocolonic location + [9, 112] Age <…
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_58 58. Pediatric Aspects of Inflammatory Bowel Disease Brendan Boyle1 and Jeffrey S. Hyams2, 3 (1) Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s…
Time period Important points Preconception – Establish care with multidisciplinary team: primary care physician, obstetrician, maternal–fetal specialist, gastroenterologist – Discontinue medications that may be harmful to fetus (i.e. methotrexate) – Update health care…
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_42 42. Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab Mindy Lam1 and Brian Bressler1 (1) Division of Gastroenterology, University of British Columbia, Vancouver, BC,…
Study Corticosteroid (starting dose) Comparator No. of patients Disease extent Duration (weeks) End-points Remission NNT (95 % CI) Intravenous Meyers [6] 1983 Hydrocortisone (300 mg daily) Corticotropin (ACTH) 120 U/day…
Fig. 31.1 Methotrexate (MTX) metabolism . MTX and its polyglutamate metabolites (MTXPG) potently inhibit dihydrofolate reductase (DHFR), impairing the conversion of dihydrofolate (FH2) to tetrahydrofolate (FH4). MTXPG also inhibit folate-dependent…
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_29 29. Steroid Therapy for Crohn’s Disease A. Hillary Steinhart1 (1) IBD Centre, Mount Sinai Hospital and Department of Medicine, University of Toronto, Room…
