In patients with Crohn’s disease (CD), anti–tumor necrosis factor (TNF) therapy is efficacious for the induction and maintenance of clinical remission, mucosal healing, reducing rates of surgery and hospitalizations, and…
Understanding the immunologic pathways in intestinal inflammation is crucial for the development of new therapies that can maximize patient response and minimize toxicity. Targeting integrins and cytokines is intended to…
Many factors influence the sexual health of people with Crohn’s disease, but active disease and depression play key roles. The fertility rate in nonoperated patients with inflammatory bowel disease with…
Crohn’s disease (CD) is a chronic inflammatory disease that confers a higher risk of cancer than in the general population. New, large, population-based studies in the past decade show that…
Edward V. Loftus Jr, MD, Editor It has been over 100 years since the Scottish surgeon Sir T. Kennedy Dalziel described several cases of “chronic interstitial enteritis” resulting in diarrhea,…
Crohn’s disease is a chronic inflammatory disorder that can progress to obstructive and penetrating complications. Although clinical symptoms are an important component of therapy, they correlate poorly with objective measures…
Individuals with a genetic predisposition to Crohn’s disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of…
Crohn’s disease (CD) is a chronic condition that can result in significant morbidity and disability. By studying the association between demographics and initial clinical features and subsequent natural history, one…
Since the discovery of the first Crohn’s disease (CD) gene NOD2 in 2001, 140 genetic loci have been found in whites using high-throughput genome-wide association studies. Several genes influence the…
Fig. 17.1 Diagnosis of Hirschsprung disease by rectal suction biopsy. (a) An adequate suction rectal biopsy should be ≥2 mm in greatest dimension and contain a generous sample of submucosa….
