Drug Formulation Delivery system Dosage form Release location Azo-bonded formulations Sulfasalazine (Azulfidine®) Azo bond of 5-ASA to sulfapyridine Broken down by colonic bacteria to release active 5-ASA moiety Tablet 500…

Participants [# Treated] Trial design Probiotic (strains) Dosing (CFU/day) Trial length (months) Ref. 103 [50] DBRDD Single strain (E. coli Nissle) 5 × 1010 3 [45] 327 [162] DBRDD Single…

Fig. 24.1 Bone formation (+) and resorption (−) during growth (From: Baron [12]) Changes in Cortical and Trabecular Bone with Growth Cortical and trabecular bone do not respond in the…

Fig. 12.1 The GH/IGF-1 axis and its role in linear growth. The hypothalamic release of growth hormone releasing hormone (GHRH) stimulates the pulsatile release of growth hormone (GH) from the…

Fig. 51.1 Conceptual scheme of the domains and variables involved in a quality-of-life assessment. The x axis represents subjective perceptions of health, the y axis represents objective health status, the…

Fig. 34.1 Azathioprine/6-mercaptopurine metabolism pathways. AZA azathioprine, GMPS guanosine monophosphate synthetase, HPRT hypoxanthine phosphoribosyltransferase, IMPDH inosine monophosphate dehydrogenase, 6-MMP 6-methylmercaptopurine, 6-MP 6-mercaptopurine, 6-TG 6-thioguanine, 6-TIMP 6-thioinosine monophosphate, TPMT thiopurine S-methyltransferase,…

Fig. 7.1 Yearly Crohn disease activity over the first 10 years after diagnosis in a Danish population of children diagnosed prior to 15 years of age (Data from Langholz et…

Fig. 13.1 Bone modeling and remodeling. (a) Bone remodeling takes place in both adults and children. It can occur in either trabecular or cortical bone as a consequence of microfractures,…