Bulk-Enhancing Agents for Stress Incontinence: Indications and Techniques

10 Bulk-Enhancing Agents for Stress Incontinence


Indications and Techniques









Patient Selection


Traditionally, UIT has been reserved for patients specifically with isolated ISD (i.e., urodynamically proven low abdominal leakpoint pressure [<100 cm H2O], limited urethral mobility, and absence of detrusor instability). With greater experience using UIT, a broader range of patients with SUI have been treated, and the technology can be applied to all types of SUI.


Good candidates for UIT generally include patients who:



An important role for UIT may be as an adjuvant treatment option after an incomplete response to more definitive treatment. Durable responses are possible in patients with persistent SUI after a failed incontinence procedure or pelvic organ prolapse surgery who were treated with collagen injection. Additionally, UIT may be considered as a “first-line” therapy, with more definitive intervention reserved (e.g., midurethral sling) for patients who fail UIT. Efficacy of subsequent incontinence procedures does not seem to be affected by previous UIT.


Finally, managing patient expectations is very important. Most women have expectations that their urine leakage will be eliminated by a single anti-incontinence surgical procedure. However, patients need to understand that UIT should be viewed as a process, rather than a single intervention, and multiple injections may be required to achieve satisfactory results.



Injection Agents—“Ideal Agent”


The success of a particular agent for UIT depends on the composition of the material, the usability of the material (ease of preparation and implantation), and the host environment where it is implanted (optimized hormonal environment, integrity of urethral mural components, and intact periurethral fascia). The ideal bulking agent should be nonimmunogenic, permanent, nonmigratory, nonerosive, and noninflammatory; be easily stored, handled, and injected; be painless; have no long-term side effects; and possess a high safety profile. Because no existing agent satisfies all these requirements, the search continues for improved materials and delivery methods.


Several agents have been developed and tested for UIT. Three commercially available bulking agents are available at the present time (Table 10-1

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May 29, 2016 | Posted by in GASTOINESTINAL SURGERY | Comments Off on Bulk-Enhancing Agents for Stress Incontinence: Indications and Techniques

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