Epidemiology of Inflammatory Bowel Disease Although inflammatory bowel disease (IBD) is found worldwide, the majority of studies have focused on white populations in North America and Europe. The incidence (or…
Inflammatory bowel disease (IBD) is classically characterized by periods of remission and clinical relapse. In some patients disease may take an aggressive course that involves frequent relapses, continued active disease,…
Clinical Significance of Fecal Biomarkers Differentiating patients with inflammatory disease from those with functional disorders may be difficult in patients with nonspecific symptoms, such as diarrhea and abdominal pain. Most…
Serologies have well-established roles in the diagnosis of a variety of immunologically driven diseases; rheumatologists rely on an alphabet soup of antibodies, hepatologists depend on serologic tests to diagnose primary…
It is surprising how little is known about disability in patients with inflammatory bowel disease (IBD). There are sparse data on IBD-related disability compared with other chronic inflammatory diseases such…
There is little debate that monoclonal antibodies directed against tumor necrosis factor-α (anti-TNFα) represent important tools in our armamentarium in the management of inflammatory bowel disease (IBD). However, the beneficial…
Randomized controlled trials support the use of the thiopurines and anti-tumor necrosis factor α (anti-TNF) monoclonal antibodies (mAb’s) in the treatment of Crohn disease (CD). Nonetheless, lack of response, loss…
Introduction and Classification of Complications of Ileal Pouch Approximately 20% to 30% of patients with ulcerative colitis (UC) eventually require surgery for failure of medical therapy or development of neoplasia….
Perianal fistula, defined as an abnormal communication between the anal canal or lower rectum and the perianal or perineal skin, is among the more morbid manifestations of Crohn disease (CD)….
Clostridium difficile is a Gram-positive anaerobe described as early as 1935 as being a member of the intestinal flora in neonates. It was not until 1978 that it was first…
