Abstract It has been known for more than 50 years that the complement system is activated in autoimmune glomerulonephritis. In recent years, evidence has emerged demonstrating that uncontrolled complement activation…
Abstract Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in white adults. It is defined by the presence of subepithelial immune deposits localized between the podocyte and…
Abstract IgA nephropathy (IgAN) is the most common pattern of glomerulonephritis in many parts of the world and remains an important cause of chronic kidney disease and end stage renal…
Abstract Glomerulonephritis (GN) relating to bacterial infections is discussed in this chapter. While a portion of the chapter is dedicated to discussing classic poststreptococcal GN, an emphasis is placed on…
Abstract The major signs and symptoms of glomerular disease are proteinuria, hematuria, reduced kidney function, edema, and hypertension. Nephrotic syndrome has more proteinuria and edema, whereas glomerulonephritic syndrome typically has…
Abstract Focal segmental glomerulosclerosis (FSGS) can be considered a set of six syndromes, including primary FSGS, adaptive FSGS, APOL1 FSGS, high-penetrance genetic FSGS, virus-associated FSGS, and medication-associated FSGS. These distinctions…
Abstract Minimal change disease (MCD) is a predominant cause of idiopathic nephrotic syndrome (NS) in children. Because most children with idiopathic NS are steroid sensitive, they are not typically biopsied,…
Chlorothiazide, which became available in 1958, ushered in the modern era of diuretic therapy, initially for the treatment of edematous states and shortly thereafter for the treatment of essential hypertension….
Abstract Disorders of mineral metabolism (calcium, phosphorus, magnesium) are common, especially in hospitalized patients. The extracellular concentrations of these ions are less than 1% of total body stores, and the…
Abstract Potassium homeostasis is regulated both by potassium excretion (primarily by the kidneys and to a smaller extent by the gut) and by potassium distribution regulated primarily by insulin and…
