Abstract Medications are crucial to the appropriate care of patients. However, acute and chronic kidney injury remains an unfortunate and relatively frequent adverse consequence of drug therapy. Although most medications…
Abstract Nephronophthisis (NPHP) is an autosomal recessive kidney disease that inevitably progresses to end-stage kidney failure within the first three decades of life. NPHP can present as isolated kidney disease…
Abstract The elucidation of monogenic diseases of tubular function has provided valuable insights into mechanisms of kidney electrolyte transport. Proximal tubular disorders include X-linked and autosomal hypophosphatemic rickets caused by…
Abstract Genetic studies of kidney diseases over the past two decades have provided novel insights into underlying pathophysiologic mechanisms and spurred progress toward the goal of precision medicine. This chapter…
Abstract Acute interstitial nephritis (AIN) is a common cause of AKI. It most commonly develops following medication exposure that illicits an immune response in the kidney. AIN also occur in…
Abstract Acid-base disorders are manifestations of underlying pathology and also very helpful clues regarding a patient’s likely differential diagnoses. When severe, acid-base derangements can themselves have deleterious effects. These disorders…
Abstract Impaired kidney function leads to altered pharmacokinetics of many drugs. This may result in clinically significant changes in systemic drug exposure and response. Individualized drug dosing regimens may be…
Abstract Initial management of acute kidney injury (AKI) includes timely recognition of the problem and correction of the underlying cause. Once established, management focuses on preventing extension of kidney injury…
Abstract Human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) are among the most important viral-induced causes of kidney disease. Each can present with a spectrum…
Abstract Acute tubular injury (ATI) is characterized by damage to the renal tubular epithelial cells from ischemic or nephrotoxic insults. There are a wide array of pathologies that can result…
