Abstract Hepatic bile formation serves a number of important functions such as critical roles in the excretion of lipid-soluble xenobiotics and endobiotics, intestinal lipid digestion and absorption, and cholesterol homeostasis….
Abstract The regulation of gastric HCl secretion by the parietal cell occurs primarily through the regulated recycling of H,K-ATPase. Secretagogue stimulation of the parietal cell initiates HCl secretion by effecting…
Abstract Pancreatic secretion is regulated by highly integrated neural and hormonal influences that involve the brain, enteric nervous system, and gastrointestinal tract. Although these processes are complex they illustrate the…
Abstract The liver is a highly specialized organ that plays a pivotal role in the detoxification of numerous substances. Toxins enter hepatocytes via a dual blood supply provided by the…
Abstract The major pathways that the liver utilizes to take up and excrete various organic anions are mediated by several facilitative uptake transporters and ATP-dependent excretory pumps. Functions of the…
Abstract The intestinal tract performs one of the most basic biologic functions, namely the harvesting of nutrients from ingested food. Moreover, the intestine participates broadly in numerous aspects of metabolism…
Abstract This chapter will discuss major recent advances that have been made in our understanding of how the different functional and neurochemical classes of enteric neurons participate in neurogenic motor…
Abstract The adaptive immune system occurs is present in only the 1% of multicellular organisms that have a longer life span and the ability to supply the high cost of…
Abstract Since their discovery > 60 years ago, tuft cells have intrigued and mystified researchers. Early studies focused on the unique morphology of tuft cells and their distribution pattern across…
Abstract The gastrointestinal barrier is more than a tissue with physiological function. As reviewed by others, it is now recognized as a complex ecosystem that requires a delicate homeostatic balance…
