Fig. 12.1 Results of two-dimensional electrophoresis and immunoblot demonstrating that circulating albumin in children migrates in the basic range of pH (lane 1–4) (Debiec et al. [18]) Fig. 12.2 Expression…
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_4 4. Co-stimulatory Molecule CD80 (B7.1) in MCNS Michiko Shimada1 , Takuji Ishimoto2 and Richard J. Johnson3 (1) Division of Cardiology and Nephrology, Hirosaki University Graduate…
Authors N IL-1 IL-2 sIL-2R IL-4 IL-5 IL-7 IL-8 IL-10 IL-12 IL-13 IL-18 IFN-γ TNF-α VEGF MCD Garin [89] 12 ↑ Cho [76] 19? ↑ ↔ Wada [110] 3 ND …
Fig. 13.1 Signalling pathways targeted by different drugs in podocytes. The glomerular capillary wall comprises of three components: glomerular endothelial cells, GBM (glomerular basement membrane) and podocytes. With its unique…
35. Savin VJ, McCarthy ET, Sharma R, Charba D, Sharma M. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl Res. 2008;151:288–92. doi:10.1016/j.trsl.2008.04.001.PubMed 36. McCarthy ET,…
Ref. TNFα IL2 IL1β IL4 IL6 IL8 IL10 IL12 IL13 IFN-γ Surany et al. [14] Serum + Serum − Serum − − Garin et al. [19] Cell mRNA + Serum…
Fig. 5.1 Protein synthesis system: Protein production is regulated and orchestrated by two signaling pathways: mTORC1 and UPR. Both pathways require ATP as an energetic currency, in which mTORC1 activation…
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_9 9. Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) in Focal Segmental Glomerulosclerosis Jochen Reiser1 and Nada Alachkar2 (1) Department of Medicine, Rush University…
© Springer Japan 2016Kazunari Kaneko (ed.)Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome10.1007/978-4-431-55270-3_1 1. History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome Kazunari Kaneko1 (1) Department of Pediatrics, Kansai Medical University, 2-5-1 Shin-machi,…
Parameters Yes No Comment Validity Is the randomization procedure well described? +1 142 on cyclosporine + steroids versus 149 best therapy at the time mostly azathioprine + steroids Double blinded? −2 Unblinded trial, thus…
